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首页> 外文期刊>BMC Urology >The role of flower pollen extract in managing patients affected by chronic prostatitis/chronic pelvic pain syndrome: a comprehensive analysis of all published clinical trials
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The role of flower pollen extract in managing patients affected by chronic prostatitis/chronic pelvic pain syndrome: a comprehensive analysis of all published clinical trials

机译：花粉提取物在治疗慢性前列腺炎/慢性盆腔疼痛综合征患者中的作用：所有已发表临床试验的综合分析

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Background Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is still a challenge to manage for all physicians. We feel that a summary of the current literature and a systematic review to evaluate the therapeutic efficacy of flower pollen extract would be helpful for physicians who are considering a phytotherapeutic approach to treating patients with CP/CPPS. Methods A comprehensive search of the PubMed and Embase databases up to June 2016 was performed. This comprehensive analysis included both pre-clinical and clinical trials on the role of flower pollen extract in CP/CPPS patients. Moreover, a meta-analysis of available randomized controlled trials (RCTs) was performed. The NIH Chronic Prostatitis Symptom Index (NIH-CPSI) and Quality of Life related questionnaires (QoL) were the most commonly used tools to evaluate the therapeutic efficacy of pollen extract. Results Pre-clinical studies demonstrated the anti-inflammatory and anti-proliferative role of pollen extract. 6 clinical, non-controlled studies including 206 patients, and 4 RCTs including 384 patients were conducted. The mean response rate in non-controlled studies was 83.6% (62.2%-96.0%). The meta-analysis revealed that flower pollen extract could significantly improve patients’ quality of life [OR 0.52 (0.34-.0.81); p =?0.02]. No significant adverse events were reported. Conclusion Most of these studies presented encouraging results in terms of variations in NIH-CPSI and QoL scores. These studies suggest that the use of flower pollen extract for the management of CP/CPPS patients is beneficial. Future publications of robust evidence from additional RCTs and longer-term follow-up would provide more support encouraging the use of flower pollen extracts for CP/CPPS patients.
机译：背景慢性前列腺炎/慢性盆腔疼痛综合征（CP / CPPS）仍然是所有医生应对的挑战。我们认为，当前文献的总结以及对花粉提取物的治疗效果进行评估的系统评价将对正在考虑采用植物治疗方法治疗CP / CPPS患者的医生有所帮助。方法对截至2016年6月的PubMed和Embase数据库进行全面搜索。这项全面的分析包括花粉提取物在CP / CPPS患者中的作用的临床前和临床试验。此外，对可用的随机对照试验（RCT）进行了荟萃分析。 NIH慢性前列腺炎症状指数（NIH-CPSI）和生活质量相关问卷（QoL）是评估花粉提取物治疗效果的最常用工具。结果临床前研究表明，花粉提取物具有抗炎和抗增殖作用。进行了6项临床非对照研究（包括206例患者）和4项RCT（包括384例患者）。非对照研究的平均缓解率为83.6％（62.2％-96.0％）。荟萃分析显示花粉提取物可以显着改善患者的生活质量[OR 0.52（0.34-.0.81）; p ＝？0.02]。没有重大不良事件的报道。结论这些研究大多数在NIH-CPSI和QoL得分的变化方面表现出令人鼓舞的结果。这些研究表明，使用花粉提取物治疗CP / CPPS患者是有益的。未来发表的来自其他RCT和长期随访的有力证据将为鼓励CP / CPPS患者使用花粉提取物提供更多支持。

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