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首页> 外文期刊>BMC Urology >A meta-analysis and The Cancer Genome Atlas data of prostate cancer risk and prognosis using epithelial cell adhesion molecule (EpCAM) expression
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A meta-analysis and The Cancer Genome Atlas data of prostate cancer risk and prognosis using epithelial cell adhesion molecule (EpCAM) expression

机译：使用上皮细胞粘附分子（EpCAM）表达的荟萃分析和《癌症基因组图谱》数据对前列腺癌的风险和预后的影响

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Epithelial cell adhesion molecule (EpCAM) expression has been reported in many types of cancer, including prostate cancer (PCa). However, the role of EpCAM expression remains inconsistent. We conducted a meta-analysis to assess the clinicopathological and prognostic significance of EpCAM expression in PCa. Publications were searched online using electronic databases. The available data were obtained from The Cancer Genome Atlas (TCGA). The odds ratios (ORs) or hazard ratios (HRs) with their 95% confidence intervals (CIs) were calculated. We identified seven studies in which immunohistochemistry was used and that included 871 prostatic tissue samples. EpCAM expression was significantly higher in PCa samples than in benign and normal tissue samples (OR?=?77.93, P?=?0.002; OR?=?161.61, P? 0.001; respectively). No correlation of EpCAM overexpression with pT stage and lymph node metastasis was observed; however, EpCAM overexpression showed a significant correlation with Gleason score (OR?=?0.48, P?=?0.012) and bone metastasis (OR?=?145.80, P? 0.001). Furthermore, TCGA data showed that EpCAM overexpression was not closely correlated with age, pT stage, lymph node metastasis, number of lymph node, prostate-specific antigen level, Gleason score, biochemical recurrence, and overall survival. Based on multivariate Cox proportional-hazards regression analysis, a significant correlation was observed between EpCAM overexpression and 5-year worse biochemical recurrence free-survival. EpCAM overexpression may be correlated with the development of bone metastasis and worse biochemical recurrence free-survival of PCa. Further studies are needed to verify these findings.
机译：上皮细胞粘附分子（EpCAM）的表达已报道在许多类型的癌症中，包括前列腺癌（PCa）。但是，EpCAM表达的作用仍然不一致。我们进行了荟萃分析，以评估EpCAM在PCa中的临床病理和预后意义。使用电子数据库在线搜索出版物。可用数据来自《癌症基因组图谱》（TCGA）。计算它们的95％置信区间（CIs）的优势比（OR）或危险比（HRs）。我们确定了七项使用免疫组织化学的研究，其中包括871个前列腺组织样品。在PCa样品中，EpCAM的表达显着高于在良性和正常组织样品中的OR（OR≥72.93，P≥0.002;OR≥161.61，P ＜0.001）。没有观察到EpCAM过表达与pT分期和淋巴结转移相关。然而，EpCAM的过表达与格里森评分（OR = 0.48，P = 0.012）和骨转移（OR = 145.80，P <0.001）显着相关。此外，TCGA数据显示，EpCAM过表达与年龄，pT分期，淋巴结转移，淋巴结数目，前列腺特异性抗原水平，格里森评分，生化复发和总生存率没有密切关系。基于多变量Cox比例风险回归分析，观察到EpCAM过表达与5年生化复发较差的自由生存之间存在显着相关性。 EpCAM的过表达可能与PCa的骨转移发展和较差的生化复发生存率相关。需要进一步研究以验证这些发现。

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