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首页> 外文期刊>BMC Veterinary Research >Changes over time in craniocerebral morphology and syringomyelia in cavalier King Charles spaniels with Chiari-like malformation
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Changes over time in craniocerebral morphology and syringomyelia in cavalier King Charles spaniels with Chiari-like malformation

机译：骑士查理王畸形骑士国王查尔斯猎犬的颅脑形态和脊髓空洞症随时间的变化

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Background Chiari-like malformation (CM) and syringomyelia is a neurological disease complex with high prevalence in cavalier King Charles spaniels (CKCS). The natural progression of this disease with time has not been described. The objectives of this study were to i) determine if syringomyelia progresses with time ii) determine if features of craniocrebral morphology previously associated with CM are progressive (including caudal cranial fossa volume, caudal cranial fossa parenchymal volume, ventricular dimensions, height of the foramen magnum and degree of cerebellar herniation). A retrospective morphometric analysis was undertaken in 12 CKCS with CM for which repeat magnetic resonance images were available without surgical intervention. Results The maximal syrinx width, height of the foramen magnum, length of cerebellar herniation and caudal cranial fossa volume increased over time. Ventricular and caudal fossa parenchymal volumes were not significantly different between scans. Conclusions The results of this study suggest that syringomyelia progresses with time. Increased caudal cranial fossa volume may be associated with active resorption of the supraoccipital bone, which has previously been found in histology specimens from adult CKCS. We hypothesise that active resorption of the supraoccipital bone occurs due to pressure from the cerebellum. These findings have important implications for our understanding of the pathogenesis and variable natural clinical progression of CM and syringomyelia in CKCS.
机译：背景Chiari样畸形（CM）和脊髓空洞症是一种神经疾病，在骑士查尔斯王猎犬（CKCS）中患病率很高。该疾病随时间的自然进展尚未描述。这项研究的目的是：i）确定脊髓空洞症是否随时间进展; ii）确定先前与CM相关的颅颅形态学特征是否是进行性的（包括尾颅窝体积，尾颅窝实质体积，心室尺寸，大孔的高度）和小脑疝的程度）。回顾性形态分析是在12 CKCS和CM中进行的，对于这些重复MRI图像无需手术即可获得。结果随着时间的推移，最大的syrinx宽度，大孔的高度，小脑疝的长度和尾颅窝的体积增加。两次扫描之间心室和尾窝的实质体积没有显着差异。结论这项研究的结果表明，脊髓空洞症随时间发展。尾颅窝增大可能与枕上骨的主动吸收有关，这在成年CKCS的组织学标本中已被发现。我们假设枕小骨的主动吸收是由于小脑的压力而发生的。这些发现对我们了解CKCS中CM和脊髓空洞症的发病机理和可变的自然临床进展具有重要意义。

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