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首页> 外文期刊>BMC Surgery >Early cytological diagnosis of extranodal stage I, primary thyroid Non-Hodgkin lymphoma in elderly patients. Report of two cases and review of the literature
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Early cytological diagnosis of extranodal stage I, primary thyroid Non-Hodgkin lymphoma in elderly patients. Report of two cases and review of the literature

机译：老年患者结外I期，原发性甲状腺非霍奇金淋巴瘤的早期细胞学诊断。两例报告及文献复习

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摘要

Primary thyroid lymphomas (PTLs) account for 5% of thyroid malignant tumors and often develop in patients with Hashimoto Thyroiditis (HT). Fine-needle cytology (FNC) is widely used in the diagnosis of thyroid nodules, including those arising in HT. Two PTL cases in HT elderly patients are here described and discussed. FNC was performed in rapidly enlarged thyroid nodules of 2 elderly patients under ultrasound (US) control. FNC was used to prepare conventional cytologic smears, immunocytochemistry (ICC) and flow cytometry (FC) assessment of cell populations. The above cases were diagnosed as well differentiated, small B-cell and diffuse large B-cell thyroid lymphomas, respectively, by means of FNC. The histological diagnoses were mucosa-associated non Hodgkin lymphoma (MALT) and diffuse large B-cell lymphoma (DLBCL), confirming FNC diagnoses, and patients were treated accordingly. FNC diagnosis of PTL is reliable and accurate; it may be conveniently used in the clinical practice since it provides indications for appropriate therapeutic procedures or diagnostic surgery, and avoids to treat benign nodules.
机译：原发性甲状腺淋巴瘤（PTL）占甲状腺恶性肿瘤的5％，常在桥本甲状腺炎（HT）患者中发展。细针细胞学检查（FNC）被广泛用于甲状腺结节的诊断，包括那些在HT中出现的结节。本文描述和讨论了HT老年患者中的两个PTL病例。 FNC是在超声（US）控制下对2位老年患者的甲状腺迅速增大的结节进行的。 FNC用于制备细胞群体的常规细胞学涂片，免疫细胞化学（ICC）和流式细胞仪（FC）评估。通过FNC分别诊断出上述病例为分化良好的小B细胞和弥散性大B细胞甲状腺淋巴瘤。组织学诊断为粘膜相关性非霍奇金淋巴瘤（MALT）和弥漫性大B细胞淋巴瘤（DLBCL），证实了FNC的诊断，并对患者进行了相应的治疗。 FNC对PTL的诊断是可靠且准确的;它可以为适当的治疗程序或诊断性手术提供适应症，并且避免治疗良性结节，因此可在临床实践中方便地使用。

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