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首页> 外文期刊>BMC research notes >Emerging threat of multidrug resistant bugs – Acinetobacter calcoaceticus baumannii complex and Methicillin resistant Staphylococcus aureus
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Emerging threat of multidrug resistant bugs – Acinetobacter calcoaceticus baumannii complex and Methicillin resistant Staphylococcus aureus

机译：多重耐药菌的新威胁–钙不动杆菌鲍曼不动杆菌复合体和耐甲氧西林的金黄色葡萄球菌

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Background Infections caused by bacteria such as multidrug resistant (MDR) Acinetobacter spp. and methicillin-resistant Staphylococcus aureus ( MRSA ) constitute a worldwide pandemic. Without gathering information about these strains, we cannot reduce the morbidity and mortality due to infections caused by these notorious bugs. Methods This study was conducted to identify the status of MDR Acinetobacter spp. and MRSA in a tertiary care centre of Nepal. Sputum, endotracheal aspirate and bronchial washing specimens were collected and processed from patients suspected of lower respiratory tract infection following standard microbiological methods recommended by the American Society for Microbiology (ASM). Double disk synergy test method was employed for the detection of extended-spectrum beta-lactamase (ESBL) in Acinetobacter isolates. Methicillin resistance in S. aureus was confirmed by using cefoxitin and oxacillin disks. Results Different genomespecies of Acinetobacter were isolated; these consisted of Acinetobacter calcoaceticus baumannii complex and A. lwoffii . Around 95% of Acinetobacter isolates were MDR, while 12.9% were ESBL-producer. Of the total 33 isolates of S. aureus , 26 (78.8%) were MDR and 14 (42.4%) were methicillin resistant. Conclusions A large number of MDR Acinetobacter spp. and MRSA has been noted in this study. The condition is worsened by the emergence of ESBL producing Acinetobacter spp. Hence, judicious use of antimicrobials is mandatory in clinical settings. Moreover, there should be vigilant surveillance of resistant clones in laboratories.
机译：背景由细菌引起的感染，例如多药耐药（MDR）不动杆菌属。耐甲氧西林的金黄色葡萄球菌（MRSA）构成世界性大流行。如果不收集有关这些菌株的信息，我们就无法降低由这些臭虫引起的感染所致的发病率和死亡率。方法进行本研究以鉴定MDR不动杆菌属的状况。和MRSA在尼泊尔的三级医疗中心。按照美国微生物学会（ASM）推荐的标准微生物学方法，从怀疑患有下呼吸​​道感染的患者中收集痰液，气管内抽吸物和支气管冲洗液样本并进行处理。采用双盘协同试验方法检测不动杆菌中的广谱β-内酰胺酶（ESBL）。通过使用头孢西丁和奥沙西林片确认金黄色葡萄球菌对甲氧西林的耐药性。结果分离出不同的不动杆菌基因组。这些由钙不动杆菌鲍曼不动杆菌复合体和芦荟组成。不动杆菌分离物中约有95％是MDR，而ESBL产生者是12.9％。在33株金黄色葡萄球菌中，耐MDR的有26株（78.8％），耐甲氧西林的有14株（42.4％）。结论大量的MDR不动杆菌属。在这项研究中已注意到MRSA。 ESBL产生不动杆菌属的出现使病情恶化。因此，在临床环境中必须明智地使用抗菌药物。此外，实验室应对耐药克隆进行警惕的监测。

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