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首页> 外文期刊>BMC research notes >Clinical characteristics and sensitivity to food and inhalants among children with eosinophilic esophagitis
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Clinical characteristics and sensitivity to food and inhalants among children with eosinophilic esophagitis

机译：嗜酸性食管炎儿童的临床特征以及对食物和吸入剂的敏感性

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Background To understand the clinical characteristics and the diagnostic procedures in pediatric patients with eosinophilic esophagitis and to evaluate the sensitivity of the patients to food and inhalant allergens. A cross-sectional study was performed in 35 children with eosinophilic esophagitis during the time period from January 2010 to January 2011. The clinical and epidemiological data were obtained using a questionnaire and medical chart analysis. The body mass index for age was used for the nutritional evaluation (via the Z score). The sensitivity to foods and inhalants was evaluated by performing a skin prick test and atopy patch test. Results Patients (35 in total, median age 10 years) with a diagnosis of eosinophilic esophagitis were evaluated. The most prevalent symptoms in the patients were vomiting (71.4%) and abdominal pain (51.4%). Endoscopic alterations were observed in 97.2% of the patients. A good nutritional state was observed in 82.8% of the children. The tests demonstrated the presence of food sensitivities and/or aeroallergens in 27 (77.1%) patients, whereas 8 (22.9%) patients did not test positive in any of the tests performed. Among the patients with positive tests, 24 (68.5%) exhibited sensitivity to aeroallergens and 16 (45.7%) were sensitive to foods. The comparison between the sensitive and insensitive groups displayed statistically significant results with respect to sex, symptom prevalence, and 24-hour esophageal pH monitoring. Conclusions The patients evaluated in this study displayed clinical characteristics of eosinophilic esophagitis similar to those reported in the literature. The sensitivity to foods determined by the tests was less than that observed in prior studies; however, a marked sensitivity to aeroallergens was observed. The different allergen sensitivity profiles observed in this study suggests that, similar to asthma, the eosinophiic esophagitis disease may exhibit several phenotypes.
机译：背景技术了解小儿嗜酸性粒细胞性食管炎的临床特征和诊断程序，并评估患者对食物和吸入性过敏原的敏感性。在2010年1月至2011年1月期间对35例嗜酸性粒细胞性食管炎患儿进行了横断面研究。使用问卷和医学图表分析获得了临床和流行病学数据。使用年龄体重指数进行营养评估（通过Z评分）。通过进行皮肤点刺试验和特应性斑贴试验评估对食物和吸入剂的敏感性。结果对诊断为嗜酸性食管炎的患者（共35例，中位年龄10岁）进行了评估。患者中最常见的症状是呕吐（71.4％）和腹痛（51.4％）。 97.2％的患者观察到内窥镜改变。在82.8％的儿童中观察到良好的营养状态。这些测试表明有27名（77.1％）患者存在食物敏感性和/或气敏性过敏原，而8名（22.9％）患者在进行的任何测试中均未呈阳性。在阳性测试的患者中，有24名（68.5％）对空气过敏原敏感，而16名（45.7％）对食物敏感。在性别，症状患病率和24小时食管pH监测方面，敏感人群和不敏感人群之间的比较显示出统计学上显着的结果。结论本研究评估的患者表现出嗜酸性食管炎的临床特征与文献报道相似。通过测试确定的食物敏感性低于以前的研究;然而，观察到对气敏原的显着敏感性。在这项研究中观察到的不同的变应原敏感性谱图表明，与哮喘相似，嗜酸性食管炎疾病可能表现出几种表型。

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