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首页> 外文期刊>BMC Immunology >Oxidative stress biomarkers and their relationship with cytokine concentrations in overweight/obese pregnant women and their neonates
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Oxidative stress biomarkers and their relationship with cytokine concentrations in overweight/obese pregnant women and their neonates

机译：超重/肥胖孕妇及其新生儿的氧化应激生物标志物及其与细胞因子浓度的关系

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Background Oxidative damage present in obese/overweight mothers may lead to further oxidative stress conditions or inflammation in maternal and cord blood samples. Thirty-four pregnant womenewborn pairs were included in this study to assess the presence of oxidative stress biomarkers and their relationship with serum cytokine concentrations. Oxidative stress biomarkers and antioxidant enzymes were compared between the mother/offspring pairs. The presence of 27 cytokines was measured in maternal and cord blood samples. Analyses were initially performed between all mothers and newborns and later between normal weight and mothers with overweight and obesity, and diabeticon-diabetic women. Results Significant differences were found in biomarker concentrations between mothers and newborns. Additionally, superoxide-dismutase activity was higher in pre-pregnancy overweight mothers compared to those with normal weight. Activity for this enzyme was higher in neonates born from mothers with normal pregestational weight compared with their mothers. Nitrites in overweight/obese mothers were statistically lower than in their offspring. Maternal free fatty acids, nitrites, carbonylated proteins, malondialdehyde and superoxide dismutase predicted maternal serum concentrations of IL-4, IL-13, IP-10 and MIP-1β. Arginase activity in maternal plasma was related to decreased concentrations of IL-4 and IL-1β in cord arterial blood. Increased maternal malondialdehyde plasma was associated with higher levels of IL-6 and IL-7 in the offspring. Conclusions Oxidative stress biomarkers differ between mothers and offspring and can predict maternal and newborn cytokine concentrations, indicating a potential role for oxidative stress in foetal metabolic and immunologic programming. Moreover, maternal obesity and diabetes may affect maternal microenvironments, and oxidative stress related to these can have an impact on the placenta and foetal growth.
机译：背景肥胖/超重母亲中存在的氧化损伤可能会导致进一步的氧化应激状况或产妇和脐带血样本中的炎症。这项研究包括了34对孕妇/新生儿，以评估氧化应激生物标志物的存在及其与血清细胞因子浓度的关系。在母亲/后代之间比较了氧化应激生物标志物和抗氧化酶。在母亲和脐带血样本中测量了27种细胞因子的存在。最初在所有母亲和新生儿之间进行分析，然后在体重正常和体重超重和肥胖的母亲以及糖尿病/非糖尿病妇女之间进行分析。结果母亲和新生儿之间的生物标志物浓度存在显着差异。另外，超重母亲的超氧化物歧化酶活性高于正​​常体重的母亲。与正常母亲相比，孕龄正常的母亲所生的新生儿对这种酶的活性更高。据统计，超重/肥胖母亲的亚硝酸盐含量低于其后代。孕妇游离脂肪酸，亚硝酸盐，羰基化蛋白，丙二醛和超氧化物歧化酶可预测孕妇血清IL-4，IL-13，IP-10和MIP-1β的浓度。孕妇血浆中的精氨酸酶活性与脐带血中IL-4和IL-1β的浓度降低有关。孕妇丙二醛血浆水平升高与后代的IL-6和IL-7水平升高有关。结论氧化应激生物标志物在母亲和后代之间有所不同，并且可以预测母体和新生儿细胞因子的浓度，表明氧化应激在胎儿代谢和免疫程序中的潜在作用。此外，母亲肥胖和糖尿病可能会影响母亲的微环境，与之相关的氧化应激会影响胎盘和胎儿的生长。

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