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Temperature modulation with an esophageal heat transfer device- a pediatric swine model study

机译：食管传热装置的温度调节-小儿猪模型研究

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Background An increasing number of conditions appear to benefit from control and modulation of temperature, but available techniques to control temperature often have limitations, particularly in smaller patients with high surface to mass ratios. We aimed to evaluate a new method of temperature modulation with an esophageal heat transfer device in a pediatric swine model, hypothesizing that clinically significant modulation in temperature (both increases and decreases of more than 1°C) would be possible. Methods Three female Yorkshire swine averaging 23 kg were anesthetized with inhalational isoflurane prior to placement of the esophageal device, which was powered by a commercially available heat exchanger. Swine temperature was measured rectally and cooling and warming were performed by selecting the appropriate external heat exchanger mode. Temperature was recorded over time in order to calculate rates of temperature change. Histopathology of esophageal tissue was performed after study completion. Results Average swine baseline temperature was 38.3°C. Swine #1 exhibited a cooling rate of 3.5°C/hr; however, passive cooling may have contributed to this rate. External warming blankets maintained thermal equilibrium in swine #2 and #3, demonstrating maximum temperature decrease of 1.7°C/hr. Warming rates averaged 0.29°C/hr. Histopathologic analysis of esophageal tissue showed no adverse effects. Conclusions An esophageal heat transfer device successfully modulated the temperature in a pediatric swine model. This approach to temperature modulation may offer a useful new modality to control temperature in conditions warranting temperature management (such as maintenance of normothermia, induction of hypothermia, fever control, or malignant hyperthermia).
机译：背景技术越来越多的病症似乎受益于温度的控制和调节，但是可用的控制温度的技术通常具有局限性，特别是在具有高表面质量比的较小患者中。我们的目标是评估一种在儿科猪模型中使用食管传热装置进行温度调节的新方法，并假设可能进行临床上显着的温度调节（升高和降低均超过1°C）。方法在放置食管装置之前，用吸入异氟烷麻醉三只雌性约重23 kg的约克郡猪，然后将其安装在市售的热交换器上。直肠测量猪的温度，并通过选择适当的外部热交换器模式进行冷却和加热。随时间记录温度，以计算温度变化率。研究完成后进行食管组织的组织病理学检查。结果平均猪基线温度为38.3°C。 1号猪的冷却速度为3.5°C /小时;但是，被动冷却可能导致了该速率。外部保温毯在2号和3号猪中保持了热平衡，表明最大温度降低了1.7°C / hr。平均升温速度为0.29°C /小时。食管组织的组织病理学分析未显示不良反应。结论食管传热装置成功地调节了小儿猪模型的温度。这种温度调节方法可提供一种有用的新方法，以在需要进行温度管理的条件下控制温度（例如维持正常体温，诱导体温过低，控制发烧或恶性体温过高）。

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