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首页> 外文期刊>BMC Bioinformatics >Stochastic modeling of aging cells reveals how damage accumulation, repair, and cell-division asymmetry affect clonal senescence and population fitness
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Stochastic modeling of aging cells reveals how damage accumulation, repair, and cell-division asymmetry affect clonal senescence and population fitness

机译：衰老细胞的随机模型揭示了损伤积累，修复和细胞分裂的不对称性如何影响克隆衰老和种群适应度

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Asymmetry during cellular division, both in the uneven partitioning of damaged cellular components and of cell volume, is a cell biological phenomenon experienced by many unicellular organisms. Previous work based on a deterministic model claimed that such asymmetry in the partitioning of cell volume and of aging-associated damage confers a fitness benefit in avoiding clonal senescence, primarily by diversifying the cellular population. However, clonal populations of unicellular organisms are already naturally diversified due to the inherent stochasticity of biological processes. Applying a model of aging cells that accounts for natural cell-to-cell variations across a broad range of parameter values, here we show that the parameters directly controlling the accumulation and repair of damage are the most important factors affecting fitness and clonal senescence, while the effects of both segregation of damaged components and division asymmetry are frequently minimal and generally context-dependent. We conclude that damage segregation and division asymmetry, perhaps counterintuitively, are not necessarily beneficial from an evolutionary perspective.
机译：在细胞分裂过程中的不对称，无论是受损细胞组分的不均匀分布还是细胞体积，都是许多单细胞生物体经历的一种细胞生物学现象。基于确定性模型的先前工作声称，这种细胞体积分配和衰老相关损伤的不对称性主要是通过使细胞数量多样化，从而在避免克隆衰老方面具有一定的健身优势。但是，由于生物过程的内在随机性，单细胞生物的克隆种群已经自然地多样化了。应用衰老细胞模型，该模型可解释各种参数值在不同细胞之间的自然变化，这里我们表明，直接控制损伤积累和修复的参数是影响适应性和克隆衰老的最重要因素，而受损组件的分离和分割不对称的影响通常很小，并且通常取决于上下文。我们得出的结论是，从进化的角度看，损害的分离和分裂的不对称性（不一定是直觉上的）不一定是有益的。

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