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首页> 外文期刊>BMC Infectious Diseases >Incidence and etiology of hemolytic-uremic syndrome in children in Norway, 1999–2008 – a retrospective study of hospital records to assess the sensitivity of surveillance
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Incidence and etiology of hemolytic-uremic syndrome in children in Norway, 1999–2008 – a retrospective study of hospital records to assess the sensitivity of surveillance

机译：挪威儿童溶血性尿毒综合症的发病率和病因，1999–2008年–一项医院记录的回顾性研究，旨在评估监测的敏感性

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Background Public awareness of hemolytic-uremic syndrome (HUS), especially related to Shiga toxin-producing Escherichia coli (STEC), has increased in Europe in recent years; accentuated in Norway by a national outbreak in 2006 and in a European context especially by the 2011 outbreak originating in Germany. As STEC surveillance is difficult due to diagnostic challenges in detecting non-O157 infections, surveillance of HUS can be used to indicate the burden of STEC infection. Until 2006, notification of HUS to the Norwegian Communicable Disease Surveillance System (MSIS) was based on microbiologically confirmed infection with enterohemorrhagic Escherichia coli (EHEC), humanpathogenic STEC. In 2006, diarrhea-associated HUS (D+HUS) was made notifiable based on clinical criteria alone. The incidence and etiology of HUS in children in Norway has not previously been described. Methods In order to assess the sensitivity of STEC and D+HUS surveillance and describe the incidence and etiology of HUS in children in Norway, we conducted a nationwide retrospective study collecting data from medical records from pediatric departments for the period 1999–2008 and compared them with data from MSIS. Descriptive statistics are presented as proportions, median, average and mean values with ranges and as incidence rates, calculated using population numbers provided by official registries. Results Forty-seven HUS cases were identified, corresponding to an average annual incidence rate of 0.5 cases per 100,000 children. Diarrhea-associated HUS was identified in 38 (81%) cases, of which the median age was 29?months, 79% were Conclusions Our results show that the incidence of HUS in children in Norway is low and suggest that D+HUS cases may be underreported when notification requires microbiological confirmation. This may also indicate underreporting of STEC infections.
机译：背景技术近年来，公众对溶血尿毒症综合征（HUS）的认识，特别是与产生志贺毒素的大肠杆菌（STEC）有关。挪威在2006年爆发了全国性疫情，在欧洲尤为突出，尤其是2011年起源于德国的疫情。由于在检测非O157感染时存在诊断挑战，因此STEC监视很困难，因此HUS监视可用于指示STEC感染的负担。直到2006年，HUS通知挪威传染病监测系统（MSIS）的依据是微生物学证实的人类致病性肠出血性肠出血性大肠杆菌（EHEC）感染。 2006年，仅根据临床标准就将腹泻相关的HUS（D + HUS）列为可通报的。挪威儿童HUS的发病率和病因学以前没有描述过。方法为了评估STEC和D + HUS监测的敏感性并描述挪威儿童HUS的发生率和病因，我们进行了一项全国性回顾性研究，收集了儿科医疗记录中的数据。 1999-2008年期间，并将其与MSIS的数据进行了比较。描述性统计数据以比例，中位数，平均值和均值以及范围和发病率表示，使用官方注册机构提供的人口数量计算得出。结果鉴定出47例HUS病例，相当于每10万名儿童的平均年发病率为0.5例。腹泻相关的HUS被鉴定为38（81％）例，中位年龄为29个月，其中79％为结论。我们的结果表明，挪威儿童中HUS的发生率较低，提示D + 当通知需要微生物确认时，HUS病例可能会被漏报。这也可能表明STEC感染报告不足。

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