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首页> 外文期刊>Brain Sciences >A Pilot Study on Brain Plasticity of Functional Connectivity Modulated by Cognitive Training in Mild Alzheimer’s Disease and Mild Cognitive Impairment
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A Pilot Study on Brain Plasticity of Functional Connectivity Modulated by Cognitive Training in Mild Alzheimer’s Disease and Mild Cognitive Impairment

机译：轻度阿尔茨海默氏病和轻度认知障碍的认知训练调节功能连接性的大脑可塑性的初步研究

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Alzheimer’s disease (AD) alters the functional connectivity of the default mode network (DMN) but also the topological properties of the functional connectome. Cognitive training (CT) is a tool to slow down AD progression and is likely to impact on functional connectivity. In this pilot study, we aimed at investigating brain functional changes after a period of CT and active control (AC) in a group of 26 subjects with mild AD (mAD), 26 with amnestic mild cognitive impairment (aMCI), and a control group of 29 healthy elderly (HE) people. They all underwent a CT and AC in a counterbalanced order following a crossover design. Resting-state functional MRI and neuropsychological testing were acquired before and after each period. We tested post-CT and post-AC changes of cognitive abilities, of the functional connectivity of the DMN, and of topological network properties derived from graph theory and network-based statistics. Only CT produced functional changes, increasing the functional connectivity of the posterior DMN in all three groups. mAD also showed functional changes in the medial temporal lobe and topological changes in the anterior cingulum, whereas aMCI showed more widespread topological changes involving the frontal lobes, the cerebellum and the thalamus. Our results suggest specific functional connectivity changes after CT for aMCI and mAD.
机译：阿尔茨海默氏病（AD）会改变默认模式网络（DMN）的功能连接性，还会改变功能连接器组的拓扑特性。认知训练（CT）是减慢AD进展的工具，可能会影响功能连接。在这项前瞻性研究中，我们旨在研究26名轻度AD（mAD），26名轻度轻度认知障碍（aMCI）受试者和对照组中经过一段时间的CT和主动控制（AC）后脑功能的变化29位健康的老年人（HE）。在交叉设计之后，它们都以平衡的顺序经历了CT和AC。在每个时期之前和之后都要进行静息状态功能性MRI和神经心理学测试。我们测试了CT后和AC后认知能力，DMN的功能连接性以及从图论和基于网络的统计数据得出的拓扑网络属性的变化。只有CT产生功能改变，从而增加了所有三组后DMN的功能连接性。 mAD还显示了颞中叶的功能变化和前扣带的拓扑变化，而aMCI显示了涉及额叶，小脑和丘脑的更广泛的拓扑变化。我们的研究结果提示aMCI和mAD的CT术后特定的功能连通性发生了变化。

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