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首页> 外文期刊>Brazilian Journal of Infectious Diseases >Metabolic effects associated to the highly active antiretroviral therapy (HAART) in AIDS patients
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Metabolic effects associated to the highly active antiretroviral therapy (HAART) in AIDS patients

机译：艾滋病患者中高效抗逆转录病毒疗法（HAART）的代谢作用

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The aim of this study was to evaluate the metabolic abnormalities (dyslipidaemia and insulin resistance) associated with highly active antiretroviral therapy (HAART) in AIDS patients, treated in Campo Grande, Mato Grosso do Sul, Brazil. The patients were distributed in five different groups: Group 1, HIV-infected without antiretroviral therapy; Group 2, with Zidovudine, Lamivudine and Efavirenz or Nevirapine; Group 3, with Zidovudine, Lamivudine and Protease Inhibitor; Group 4, with Stavudine, Lamivudine and Efavirenz or Nevirapine; and Group 5, with Stavudine, Lamivudine and Protease Inhibitor. The lipid and glucose profile were determined and statistics comparison was made. The findings of this study showed significant statistics elevations of total cholesterol and triglycerides levels in patients of Groups 3, 4 and 5, when comparing to patients of Groups 1 and 2. Significant differences were not observed between the groups in the others parameters evaluated: Glucose, HDL cholesterol and LDL cholesterol. Comparing two drugs of same class (NNRTI) through the subgroups II-efavirenz and II-nevirapine, significant differences in the serum levels of total cholesterol, triglycerides and glucose favorable to the subgroup II-NVP were observed. These findings suggest that combinations including Protease Inhibitors and/or Stavudine could cause more adverse metabolic effects, and if possible, should be avoided in patients with others cardiovascular risk factors to prevent the precocious atherosclerosis in AIDS patients receiving HAART.
机译：这项研究的目的是评估在巴西南马托格罗索州坎普格兰德市进行治疗的艾滋病患者中与高效抗逆转录病毒疗法（HAART）相关的代谢异常（血脂异常和胰岛素抵抗）。将患者分为五个不同的组：第1组，未经抗逆转录病毒治疗的HIV感染者;第1组。第2组，齐多夫定，拉米夫定和依非韦伦或奈韦拉平;第3组，齐多夫定，拉米夫定和蛋白酶抑制剂;第4组，含司他夫定，拉米夫定和依非韦伦或奈韦拉平;第5组，含Stavudine，Lamivudine和蛋白酶抑制剂。测定脂质和葡萄糖谱并进行统计比较。这项研究的结果表明，与第1组和第2组的患者相比，第3、4和5组的患者的总胆固醇和甘油三酯水平显着升高。在其他评估参数中，两组之间未观察到显着差异。 ，HDL胆固醇和LDL胆固醇。通过II-依法韦仑和II-奈韦拉平亚组比较两种相同类别的药物（NNRTI），观察到总胆固醇，甘油三酸酯和葡萄糖的血清水平对II-NVP亚组有显着差异。这些发现表明，包括蛋白酶抑制剂和/或Stavudine的组合可能引起更多的不良代谢作用，如果可能，应避免在具有其他心血管危险因素的患者中使用，以预防接受HAART的AIDS患者的早熟性动脉粥样硬化。

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