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首页> 外文期刊>Brazilian Journal of Infectious Diseases >The effects of nitric oxide on the immune response during giardiasis
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The effects of nitric oxide on the immune response during giardiasis

机译：一氧化氮对贾第鞭毛虫病免疫反应的影响

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Nitric oxide (NO) is a free radical synthesized from L-arginine by different isoforms NO-synthases. NO possesses multiple and complex biological functions. NO is an important mediator of homeostasis, and changes in its generation or actions can contribute or not to pathological states. The knowledge of effects of NO has been not only important to our understanding of immune response, but also to new tools for research and treatment of various diseases. Knowing the importance of NO as inflammatory mediator in diverse infectious diseases, we decided to develop a revision that shows the participation/effect of this mediator in immune response induced against Giardia spp. Several studies already demonstrated the participation of NO with microbicidal and microbiostatic activity in giardiasis. On the other hand, some works report that Giardia spp. inhibit NO production by consuming the intermediate metabolite arginine. In fact, studies in vitro showed that G. lamblia infection of human intestinal epithelial cells had reduced NO production. This occurs due to limited offer of the crucial substrate arginine (essential aminoacid for NO production), consequently reducing NO production. Therefore, the balance between giardial arginine consumption and epithelial NO production could contribute to the variability of the duration and severity of infections by this ubiquitous parasite.
机译：一氧化氮（NO）是由L-精氨酸通过不同的亚型NO合酶合成的自由基。 NO具有多种复杂的生物学功能。 NO是体内稳态的重要调节剂，其生成或作用的变化可以促进或不促进病理状态。一氧化氮的作用知识不仅对我们对免疫反应的理解很重要，而且对研究和治疗各种疾病的新工具也很重要。了解了NO在多种传染病中作为炎症介质的重要性，我们决定开发一种修订版，以显示该介质在针对贾第鞭毛虫诱导的免疫反应中的参与/作用。几项研究已经证明NO参与了贾第鞭毛虫病的杀微生物和抑菌活性。另一方面，一些作品报告说贾第鞭毛虫属。通过消耗中间代谢产物精氨酸抑制NO的产生。实际上，体外研究表明，人肠上皮细胞的兰氏芽孢杆菌感染减少了NO的产生。这是由于关键底物精氨酸（用于产生NO的必需氨基酸）的供应有限而导致的，因此降低了NO的产生。因此，贾第虫精氨酸消耗和上皮NO产生之间的平衡可能会导致这种无处不在的寄生虫感染的持续时间和严重程度的差异。

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