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首页> 外文期刊>Brain Sciences >Adolescent Alcohol Drinking Renders Adult Drinking BLA-Dependent: BLA Hyper-Activity as Contributor to Comorbid Alcohol Use Disorder and Anxiety Disorders
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Adolescent Alcohol Drinking Renders Adult Drinking BLA-Dependent: BLA Hyper-Activity as Contributor to Comorbid Alcohol Use Disorder and Anxiety Disorders

机译：青少年饮酒致使成年人饮酒依赖BLA：BLA过度活跃是导致合并酒精使用障碍和焦虑症的原因

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Adolescent alcohol drinking increases the risk for alcohol-use disorder in adulthood. Yet, the changes in adult neural function resulting from adolescent alcohol drinking remain poorly understood. We hypothesized that adolescent alcohol drinking alters basolateral amygdala (BLA) function, making alcohol drinking BLA-dependent in adulthood. Male, Long Evans rats were given voluntary, intermittent access to alcohol (20% ethanol) or a bitter, isocaloric control solution, across adolescence. Half of the rats in each group received neurotoxic BLA lesions. In adulthood, all rats were given voluntary, intermittent access to alcohol. BLA lesions reduced adult alcohol drinking in rats receiving adolescent access to alcohol, but not in rats receiving adolescent access to the control solution. The effect of the BLA lesion was most apparent in high alcohol drinking adolescent rats. The BLA is essential for fear learning and is hyper-active in anxiety disorders. The results are consistent with adolescent heavy alcohol drinking inducing BLA hyper-activity, providing a neural mechanism for comorbid alcohol use disorder and anxiety disorders.
机译：青少年饮酒会增加成年期酒精使用障碍的风险。然而，青少年饮酒导致成人神经功能的变化仍然知之甚少。我们假设青春期饮酒会改变基底外侧杏仁核（BLA）功能，从而使成年期饮酒依赖BLA。在整个青春期，雄性Long Evans大鼠均自愿，间歇性地使用酒精（20％乙醇）或苦味，等温的对照溶液。每组一半的大鼠受到神经毒性的BLA损害。成年后，所有大鼠均自愿，间歇性饮酒。 BLA病变会减少接受青春期饮酒的大鼠的成年饮酒，但不会降低接受青春期对照溶液的大鼠的成年饮酒。 BLA病变的影响在高饮酒的青春期大鼠中最为明显。 BLA对于恐惧学习至关重要，并且在焦虑症中活跃。该结果与青少年重度饮酒诱导BLA过度活跃是一致的，为并存酒精使用障碍和焦虑症提供了神经机制。

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