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首页> 外文期刊>Brazilian Journal of Infectious Diseases >Body composition and lipodystrophy in prepubertal HIV-infected children
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Body composition and lipodystrophy in prepubertal HIV-infected children

机译：青春期前感染艾滋病毒的儿童的身体成分和脂肪营养不良

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OBJECTIVE: To identify lipodystrophy in prepubertal HIV-infected children using anthropometric parameters and body composition assessment. METHODS: Cross-sectional study including 40 prepubertal HIV-infected children of both genders seen at the Care Center of the Division of Pediatric Infectious Diseases - Universidade Federal de S?o Paulo, S?o Paulo city, Brazil, was carried out from August to December 2008. Age, clinical and immunological status, prophylaxis, transmission and highly active antiretroviral therapy were recorded. Body mass index z-score and height-for-age z-score were calculated to characterize the nutritional status. Circumferences were measured with flexible tape and skinfolds were assessed by an adipometry. Fat mass and lean mass were determined by dual-energy X-ray absorptiometry. Presence of clinical signs of lipodystrophy was assessed by a trained clinician. Data were analyzed using SPSS 12.0 software. RESULTS: The mean age and standard deviation were 9.8 (1.2) years, 50% were girls and 82.5% children from B and C categories. Clinical lipodystrophy and dislypidemia were present in 27.5% and 70%, respectively. The trunk to arm ratio and the limb to trunk ratio had positive association with lipodystrophy. Patients with lipodystrophy had short stature, higher triglycerides values and lower HDL-cholesterol. CONCLUSION: The ratios obtained by skinfolds and dual-energy X-ray absorptiometry measurements can be considered as indicators of preclinical lipodystrophy. The cutoff points have not been determined yet; however, continuous assessment may be useful to identify early body composition changes.
机译：目的：通过人体测量学参数和身体成分评估来鉴定青春期前感染艾滋病毒的儿童的脂肪营养不良。方法：从八月开始，在巴西圣保罗联邦大学儿科传染病科的护理中心对包括40个性别的青春期前受艾滋病毒感染的两性儿童进行了横断面研究。至2008年12月。记录年龄，临床和免疫学状况，预防，传播和高效抗逆转录病毒疗法。计算了体重指数z得分和年龄别高度z得分以表征营养状况。用软胶带测量周长，并通过脂肪测定法评估皮褶。脂肪量和瘦肉量通过双能X射线吸收法测定。由训练有素的临床医生评估脂肪营养不良的临床体征。使用SPSS 12.0软件分析数据。结果：B和C类的平均年龄和标准差为9.8（1.2）岁，女孩为50％，儿童为82.5％。临床脂肪营养不良和血脂异常分别占27.5％和70％。躯干比和肢干比与脂肪营养不良呈正相关。脂肪营养不良的患者身材矮小，甘油三酸酯值较高，HDL-胆固醇较低。结论：通过皮褶皱和双能X线吸收仪测量获得的比率可被认为是临床前脂肪营养不良的指标。截止点尚未确定;但是，连续评估可能有助于识别早期的身体成分变化。

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