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首页> 外文期刊>Brazilian Journal of Medical and Biological Research >Drag reduction by polyethylene glycol in the tail arterial bed of normotensive and hypertensive rats
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Drag reduction by polyethylene glycol in the tail arterial bed of normotensive and hypertensive rats

机译：正常血压和高血压大鼠尾动脉床中聚乙二醇的减阻作用

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This study was designed to evaluate the effect of drag reducer polymers (DRP) on arteries from normotensive (Wistar) and spontaneously hypertensive rats (SHR). Polyethylene glycol (PEG 4000 at 5000 ppm) was perfused in the tail arterial bed with (E+) and without endothelium (E-) from male, adult Wistar (N = 14) and SHR (N = 13) animals under basal conditions (constant flow at 2.5 mL/min). In these preparations, flow-pressure curves (1.5 to 10 mL/min) were constructed before and 1 h after PEG 4000 perfusion. Afterwards, the tail arterial bed was fixed and the internal diameters of the arteries were then measured by microscopy and drag reduction was assessed based on the values of wall shear stress (WSS) by computational simulation. In Wistar and SHR groups, perfusion of PEG 4000 significantly reduced pulsatile pressure (Wistar/E+: 17.5 ± 2.8; SHR/E+: 16.3 ± 2.7%), WSS (Wistar/E+: 36; SHR/E+: 40%) and the flow-pressure response. The E- reduced the effects of PEG 4000 on arteries from both groups, suggesting that endothelial damage decreased the effect of PEG 4000 as a DRP. Moreover, the effects of PEG 4000 were more pronounced in the tail arterial bed from SHR compared to Wistar rats. In conclusion, these data demonstrated for the first time that PEG 4000 was more effective in reducing the pressure-flow response as well as WSS in the tail arterial bed of hypertensive than of normotensive rats and these effects were amplified by, but not dependent on, endothelial integrity. Thus, these results show an additional mechanism of action of this polymer besides its mechanical effect through the release and/or bioavailability of endothelial factors.
机译：本研究旨在评估减阻聚合物（DRP）对血压正常（Wistar）和自发性高血压（SHR）大鼠动脉的影响。在基础条件下（恒定），在雄性，成年Wistar（N = 14）和SHR（N = 13）雄性动物的尾动脉床中灌注含（E +）和不含内皮（E-）的聚乙二醇（PEG 4000，浓度为5000 ppm）流速为2.5 mL / min）。在这些制剂中，在PEG 4000灌注之前和之后1小时绘制了流量-压力曲线（1.5至10 mL / min）。之后，固定尾动脉床，然后通过显微镜测量动脉的内径，并通过计算模拟基于壁切应力（WSS）的值评估减阻。在Wistar和SHR组中，灌注PEG 4000显着降低了脉动压力（Wistar / E +：17.5±2.8; SHR / E +：16.3±2.7％），WSS（Wistar / E +：36; SHR / E +：40％）和流动压力响应。 E-降低了两组中PEG 4000对动脉的作用，表明内皮损伤降低了PEG 4000作为DRP的作用。此外，与Wistar大鼠相比，SHR的尾动脉床中PEG 4000的作用更为明显。总之，这些数据首次证明PEG 4000在降低高血压大鼠尾动脉床上的压力-流量反应以及WSS方面比正常血压大鼠更有效，并且这些作用通过但不依赖于以下因素得到了放大：内皮完整性。因此，这些结果表明该聚合物除了通过内皮因子的释放和/或生物利用度的机械作用外，还具有其他作用机理。

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