• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Brazilian Journal of Medical and Biological Research >H1 but not H2 histamine antagonist receptors mediate anxiety-related behaviors and emotional memory deficit in mice subjected to elevated plus-maze testing
【24h】

H1 but not H2 histamine antagonist receptors mediate anxiety-related behaviors and emotional memory deficit in mice subjected to elevated plus-maze testing

机译：H1但不是H2组胺拮抗剂受体介导进行高迷宫测试的小鼠的焦虑相关行为和情绪记忆障碍

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study investigated the role of H1 and H2 receptors in anxiety and the retrieval of emotional memory using a Trial 1/Trial 2 (T1/T2) protocol in an elevated plus-maze (EPM). Tests were performed on 2 consecutive days, designated T1 and T2. Before T1, the mice received intraperitoneal injections of saline (SAL), 20?mg/kg zolantidine (ZOL, an H2 receptor antagonist), or 8.0 or 16?mg/kg chlorpheniramine (CPA, an H1 receptor antagonist). After 40?min, they were subjected to the EPM test. In T2 (24?h later), each group was subdivided into two additional groups, and the animals from each group were re-injected with SAL or one of the drugs. In T1, the Student t-test showed no difference between the SAL and ZOL or 8?mg/kg CPA groups with respect to the percentages of open arm entries (%OAE) and open arm time (%OAT). However, administration of CPA at the highest dose of 16?mg/kg decreased %OAE and %OAT, but not locomotor activity, indicating anxiogenic-like behavior. Emotional memory, as revealed by a reduction in open arm exploration between the two trials, was observed in all experimental groups, indicating that ZOL and 8?mg/kg CPA did not affect emotional memory, whereas CPA at the highest dose affected acquisition and consolidation, but not retrieval of memory. Taken together, these results suggest that H1 receptor, but not H2, is implicated in anxiety-like behavior and in emotional memory acquisition and consolidation deficits in mice subjected to EPM testing.
机译：这项研究调查了H1和H2受体在焦虑和情绪记忆的恢复中使用高架迷宫（EPM）中的试验1 /试验2（T1 / T2）方案。测试连续2天进行，分别为T1和T2。在T1之前，小鼠接受腹膜内注射生理盐水（SAL），20？mg / kg佐兰定（ZOL，H2受体拮抗剂）或8.0或16？mg / kg氯苯那敏（CPA，H1受体拮抗剂）。 40分钟后，他们接受了EPM测试。在T2（24小时后）中，将每组再分为两组，然后将每组中的动物注射SAL或其中一种药物。在T1中，Student t检验显示，在SAL和ZOL或8？mg / kg CPA组之间，相对于张开双臂的百分比（％OAE）和张开双臂的时间（％OAT），没有差异。但是，以最高16？mg / kg的剂量施用CPA可以降低％OAE和％OAT，但不能降低运动活性，表明有类似焦虑的行为。在所有实验组中均观察到情绪记忆，这是通过两次试验之间的开臂探查减少而得出的，表明ZOL和8？mg / kg CPA不会影响情绪记忆，而最高剂量的CPA会影响获取和巩固，但不检索内存。综上所述，这些结果表明，在接受EPM测试的小鼠中，H1受体而非H2参与了焦虑样行为，情绪记忆获得和巩固缺陷。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号