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首页> 外文期刊>Brazilian Journal of Medical and Biological Research >Effects of Lippia sidoides essential oil, thymol, p-cymene, myrcene and caryophyllene on rat sciatic nerve excitability
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Effects of Lippia sidoides essential oil, thymol, p-cymene, myrcene and caryophyllene on rat sciatic nerve excitability

机译：西番莲精油，百里香酚，对伞花烃，月桂烯和石竹烯对大鼠坐骨神经兴奋性的影响

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Lippia sidoides Cham is a typical herb species of Northeast Brazil with widespread use in folk medicine. The major constituents of the essential oil of L. sidoides (EOLs) are thymol, p-cymene, myrcene, and caryophyllene. Several studies have shown that the EOLs and its constituents have pharmacological effects, including antibacterial, anti-inflammatory, antioxidant and neuroprotective activity. Therefore, this work aimed to investigate the effects of the EOLs and their main constituents on rat sciatic nerve excitability. The sciatic nerves of adult Wistar rats were dissected and mounted in a moist chamber. Nerves were stimulated by square wave pulses, with an amplitude of 40 V, duration of 100 μs to 0.2 Hz. Both EOLs and thymol inhibited compound action potential (CAP) in a concentration-dependent manner. Half maximal inhibitory concentration for CAP peak-to-peak amplitude blockade were 67.85 and 40 μg/mL for EOLs and thymol, respectively. CAP peak-to-peak amplitude was significantly reduced by concentrations ≥60 μg/mL for EOLs and ≥30 μg/mL for thymol. EOLs and thymol in the concentration of 60 μg/mL significantly increased chronaxie and rheobase. The conduction velocities of 1st and 2nd CAP components were also concentration-dependently reduced by EOLs and thymol in the range of 30-100 μg/mL. Differently from EOLs and thymol, p-cymene, myrcene and caryophyllene did not reduce CAP in the higher concentrations of 10 mM. These data demonstrated that EOLs and thymol inhibited neuronal excitability and were promising agents for the development of new drugs for therapeutic use.
机译：Lippia sidoides Cham是巴西东北部的一种典型草药，广泛用于民间医学。枸杞子（EOLs）精油的主要成分是百里香酚，对伞花烃，月桂烯和石竹烯。多项研究表明，EOL及其成分具有药理作用，包括抗菌，消炎，抗氧化剂和神经保护活性。因此，这项工作旨在调查EOL及其主要成分对大鼠坐骨神经兴奋性的影响。解剖成年Wistar大鼠的坐骨神经并将其安装在潮湿的房间中。用方波脉冲刺激神经，振幅为40 V，持续时间为100μs至0.2 Hz。 EOL和百里酚均以浓度依赖的方式抑制复合动作电位（CAP）。 EOL和百里酚对CAP峰-峰振幅阻断的最大半数抑制浓度分别为67.85和40μg/ mL。 EOLs浓度≥60μg/ mL，百里酚浓度≥3​​0μg/ mL时，CAP峰峰值幅度显着降低。浓度为60μg/ mL的EOL和百里酚显着增加了chronaxie和rheobase。 EOL和百里酚在30-100μg/ mL的范围内，浓度依赖性地降低了第一和第二CAP组分的传导速度。与EOL和百里酚不同的是，在10 mM的较高浓度下，对伞花烃，月桂烯和石竹烯不会降低CAP。这些数据表明，EOL和百里酚可抑制神经元兴奋性，是开发治疗用新药的有前途的药物。

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