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首页> 外文期刊>Brazilian Journal of Medical and Biological Research >Swimming training down-regulates plasma leptin levels, but not adipose tissue ob mRNA expression
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Swimming training down-regulates plasma leptin levels, but not adipose tissue ob mRNA expression

机译：游泳训练下调血浆瘦素水平，但不下调脂肪组织ob mRNA表达

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The aim of the present study was to assess the effects of endurance training on leptin levels and adipose tissue gene expression and their association with insulin, body composition and energy intake. Male Wistar rats were randomly divided into two groups: trained (N = 18) and sedentary controls (N = 20). The trained group underwent swimming training for 9 weeks. Leptin and insulin levels, adiposity and leptin gene expression in epididymal and inguinal adipose tissue were determined after training. There were no differences in energy intake between groups. Trained rats had a decreased final body weight (-10%), relative and total body fat (-36 and -55%, respectively) and insulin levels (-55%) compared with controls (P < 0.05). Although trained animals showed 56% lower leptin levels (2.58 ± 1.05 vs 5.89 ± 2.89 ng/mL in control; P < 0.05), no difference in leptin gene expression in either fat depot was demonstrable between groups. Stepwise multiple regression analysis showed that lower leptin levels in trained rats were due primarily to their lower body fat mass. After adjustment for total body fat, leptin levels were still 20% (P < 0.05) lower in exercised rats. In conclusion, nine weeks of swimming training did not affect leptin gene expression, but did lead to a decrease in leptin levels that was independent of changes in body fat.
机译：本研究的目的是评估耐力训练对瘦素水平和脂肪组织基因表达的影响及其与胰岛素，身体成分和能量摄入的关系。将雄性Wistar大鼠随机分为两组：训练组（N = 18）和久坐对照组（N = 20）。训练有素的小组接受了9周的游泳训练。训练后测定附睾和腹股沟脂肪组织中的瘦素和胰岛素水平，肥胖和瘦素基因表达。两组之间的能量摄入没有差异。与对照组相比，训练有素的大鼠的最终体重（-10％），相对脂肪和总脂肪（分别为-36和-55％）和胰岛素水平（-55％）有所降低（P <0.05）。尽管受过训练的动物的瘦素水平降低了56％（对照组为2.58±1.05 vs 5.89±2.89 ng / mL; P <0.05），但两组之间在任一脂肪库中的瘦素基因表达均无差异。逐步多元回归分析表明，训练有素的大鼠中瘦素水平较低主要是由于它们的体内脂肪量较低。调整体内总脂肪后，运动大鼠的瘦素水平仍然降低20％（P <0.05）。总之，游泳训练的九周时间不会影响瘦素基因的表达，但是会导致瘦素水平的降低，而这种降低与体脂的变化无关。

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