Estrogen receptor-β: why may it influence clinical outcome in estrogen receptor-α positive breast cancer?

Margaret A Shupnik

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Estrogen receptor-β: why may it influence clinical outcome in estrogen receptor-α positive breast cancer?

机译：雌激素受体-β：为什么会影响雌激素受体-α阳性乳腺癌的临床结局？

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In the previous issue of the journal, Lin and coworkers present data demonstrate that increased expression of estrogen receptor (ER)-β in ER-α-positive breast cancer cells antagonizes a defined group of ER-α/estrogen stimulated genes that are involved in cell cycle regulation and DNA replication. Similar expression patterns for these genes were found human ER-α positive breast tumors expressing higher levels or ER-β, and this correlated with better clinical outcome. The implications for these data, which suggest that ER-β is a positive actor and diagnostic marker for therapeutic outcome, are discussed.

机译：在上一期杂志中，Lin及其同事提供的数据表明，ER-α阳性乳腺癌细胞中雌激素受体（ER）-β的表达增加可拮抗一组与ER-α/雌激素刺激有关的基因细胞周期调节和DNA复制。这些基因的相似表达模式被发现表达较高水平或ER-β的人ER-α阳性乳腺肿瘤，这与更好的临床结果相关。讨论了这些数据的含义，这些数据表明ER-β是治疗结果的阳性因子和诊断标记。

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《Breast Cancer Research》 |2007年第3期|共页
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Margaret A Shupnik;
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中图分类泌尿生殖器肿瘤;
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1. Estrogen receptor-β: why may it influence clinical outcome in estrogen receptor-α positive breast cancer? [J] . Margaret A Shupnik Breast Cancer Research . 2007,第3期

机译：雌激素受体-β：为什么会影响雌激素受体-α阳性乳腺癌的临床结局？
2. Protein kinase C- a downregulates estrogen receptor- a by suppressing c- Jun phosphorylation in estrogen receptor- positive breast cancer cells [J] . Kim Sangmin, Lee Jeongmin, Lee Se Kyung, Oncology reports . 2014,第3期

机译：蛋白激酶C-α通过抑制雌激素受体阳性乳腺癌细胞中的c-Jun磷酸化而下调雌激素受体-α
3. Estrogen receptor-β status influences clinical outcome of triple-negative breast cancer [J] . Goi Sakamoto, Naoko Honma Breast Cancer . 2009,第4期

机译：雌激素受体-β状态影响三阴性乳腺癌的临床结果
4. Study on Molecular Docking of Red Betel (Piper Crocatum Ruiz Pav.) Active Compound and Tamoxifen Drug as an Inhibitor of Estrogen Receptor-α (ER-α) that Plays a Role in Breast Cancer [C] . Siti Imroatul Maslikah, Sri Rahayu Lestari, Nursasi Handayani, International Conference on Life Sciences and Technology . 2020

机译：红色槟榔（吹笛茶叶ruiz＆pav.）活性化合物和三氧化物药物作为发挥乳腺癌作用的雌激素受体-α（ER-α）抑制剂的研究
5. Mechanisms of Action and Efficacy Modulation of Novel Retinoic Acid Metabolism Blocking Agent (RAMBA) VN/12-1 in Estrogen Receptor-α Negative Breast Cancer Model Systems: Targeting Autophagy [D] . Godbole, Abhijit Moreshwar 2011

机译：新型视黄酸代谢阻断剂（RAMBA）VN / 12-1在雌激素受体-α阴性乳腺癌模型系统中的作用和功效调节机制：靶向自噬
6. Estrogen receptor-β: why may it influence clinical outcome in estrogen receptor-α positive breast cancer? [O] . Margaret A Shupnik 2007

机译：雌激素受体-β：为什么会影响雌激素受体-α阳性乳腺癌的临床结局？
7. Estrogen receptor-β: why may it influence clinical outcome in estrogen receptor-α positive breast cancer? [O] . Shupnik, Margaret A 2007

机译：雌激素受体-β：为什么会影响雌激素受体-α阳性乳腺癌的临床结局？

Estrogen receptor-β: why may it influence clinical outcome in estrogen receptor-α positive breast cancer?

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