• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>British Biotechnology Journal >Anti-Inflammatory and Analgesic Activities ofSoft Drink Leaf Extract of Phyllanthus amarusin Some Laboratory Animals
【24h】

Anti-Inflammatory and Analgesic Activities ofSoft Drink Leaf Extract of Phyllanthus amarusin Some Laboratory Animals

机译：mar叶软饮叶提取物的消炎镇痛作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aim: Phyllanthus amarus Schum (Euphorbiaceae) is an annual herbal shrub which has been used in traditional medicine in Nigeria to treat some disease conditions. The aim of this study is to evaluate the anti-inflammatory and analgesic activities of the aqueous extract of Phyllanthus amarus in experimental animal models hence confirming its folkloric use.Study Design: Forty healthy white Wister strain albino rats (100–200g) and forty mice (15–30g) of either sex bred in the experimental animal house of the Faculty of Veterinary Medicine, University of Ibadan, Nigeria were used for the study. Forty rats were used for anti-inflammatory study while forty mice used for the analgesic study. In anti-inflammatory study, carrageenan and histamine-induced paw oedema were used while acetic acid-induced writhing test and formalin-induced paw lick test were deployed for analgesic test. Place and Duration of Study: Faculty of Veterinary Medicine, University of Ibadan, Nigeria; 2 months.Methodology: Soft drink extract (SDE) was prepared by dissolving ground plant materials (200g) in 1 L seven up (7 UP?) for 48 h, filtered, lyophilized and then used for the pharmacological investigations. Standard phytochemical methods were used to test for the presence of phytoactive compounds in the plant. Acute toxicity was carried out in mice to determine safe doses for use. The anti-inflammatory activities were conducted using carrageenan and histamine to induce oedema in rats while analgesic activities were embarked upon using acetic acid- induced writhing test and formalin-induced paw lick test. Results: The extract in doses of 100 and 200 mg/kg at 3 hr showed 15.1 and 16.4% inhibition of histamine induced-paw oedema respectively while ibuprofen caused 9.6% inhibition at the same period. In the case of carrageenan induced paw oedema, the extract in doses of 100 and 200 mg/kg at 4 hr showed 10.5 and 12.0% inhibition respectively while ibuprofen only caused 3% inhibition. In the acetic acid- induced writhing test, the extract showed a good analgesic activity characterized by a significant reduction in the number of writhes with 100 and 200 mg/kg doses used when compared to the control group. The result was also similar to the formalin-induced paw lick test. Conclusion: The soft drink leaf extract of Phyllanthus amarus has both analgesic and anti-inflammatory potential. The activities of this extract were comparable to that of ibuprofen, the reference drug used in this study.
机译：目的：Phyllanthus amarus Schum（大叶菊科）是一种一年生草本灌木，在尼日利亚已被用于传统医学中以治疗某些疾病。这项研究的目的是在实验动物模型中评估a兰​​水提物的抗炎和镇痛作用，从而证实其民间用途。研究设计：40只健康的Wister白变种白化病大鼠（100–200g）和40只小鼠（15-30g）在尼日利亚伊巴丹大学兽医学院实验动物房中繁殖的任何性别都用于研究。四十只大鼠用于抗炎研究，四十只小鼠用于镇痛研究。在抗炎研究中，使用了角叉菜胶和组胺引起的爪水肿，同时使用乙酸诱导的扭体试验和福尔马林诱导的爪舔试验进行镇痛试验。学习地点和持续时间：尼日利亚伊巴丹大学兽医学院; 2个月。方法：通过将磨碎的植物材料（200g）溶解在1升七升（7 UP？）中48小时，过滤，冻干然后用于药理研究，制备软饮料提取物（SDE）。使用标准植物化学方法测试植物中植物活性化合物的存在。在小鼠中进行了急性毒性以确定安全的使用剂量。使用角叉菜胶和组胺进行抗炎活性，以诱导大鼠水肿，同时使用乙酸诱导的扭体试验和福尔马林诱导的爪舔试验开始镇痛活性。结果：在3小时的100和200 mg / kg剂量的提取物中，组胺诱导的爪水肿分别抑制15.1和16.4％，而布洛芬在同一时期抑制9.6％。在角叉菜胶诱发的足水肿的情况下，以100和200 mg / kg的剂量在4小时时提取物分别表现出10.5和12.0％的抑制作用，而布洛芬仅引起3％的抑制作用。在乙酸诱导的扭体试验中，提取物显示出良好的镇痛活性，其特征在于，与对照组相比，使用100和200 mg / kg剂量的扭伤次数显着减少。该结果也与福尔马林诱导的爪舔试验相似。结论：苦竹叶提取物具有止痛和消炎作用。该提取物的活性与本研究中使用的参考药物布洛芬相当。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号