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首页> 外文期刊>British Biotechnology Journal >Effects of Estrogen and Folic Acid on High FatInduced Hypercholesterolemic Mice
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Effects of Estrogen and Folic Acid on High FatInduced Hypercholesterolemic Mice

机译：雌激素和叶酸对高脂诱导的高胆固醇血症小鼠的影响

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Aims: To elucidate the effect of estrogen and folic acid on high fat (butter) induced lipid profile (total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), and triglyceride (TG)) and on tissue texture changes in mice. Designs: Randomized block design.Place and Duration of Study: Department of Physiology and Department of Pathology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh between January 2012 and April2012.Methodology: 2 months old 50 male Swiss Albino mice (Mus musculus) were used for this study and divided into equal groups. Group A (control) was fed with normal rat pellet. Mice in the group B was fed with butter; group C was fed with butter and estrogen; group D was fed with butter and folic acid and group E was fed with butter, estrogen and folic acid. The atheroprotective effect of estrogen and folic acid was evaluated based on weight gain, biochemical parameters and histopathology.Results: The highest body weight gain was detected in group B (PPPP<0.001). In histo-pathological study, the aorta of butter treated group showed sloughing of lining endothelium, increased aortic wall thickness and loss of integrity of tunica intima. It also revealed fatty changes in liver in animal models fed with butter, compared with those on a normal diet. Conclusions: 20% butter supplementation would be able to cause a rise in lipid profile and produce degenerative changes in aorta and liver and addition of estrogen or folic acid in butter supplemented diet counteracts the adverse effect.
机译：目的：阐明雌激素和叶酸对高脂（黄油）诱导的脂质分布（总胆固醇（TC），低密度脂蛋白（LDL），高密度脂蛋白（HDL）和甘油三酸酯（TG））和组织的影响小鼠的质地变化。设计：随机区组设计研究地点和持续时间：孟加拉国农业大学兽医学院生理学系和病理学系，孟加拉国Mymensingh-2202，2012年1月至2012年4月之间方法：2个月大50只雄性瑞士白化小鼠（Mus musculus）用于这项研究，并分为相等的组。给A组（对照组）喂食正常大鼠颗粒。 B组的小鼠喂黄油。 C组饲喂黄油和雌激素; D组喂食黄油和叶酸，E组喂食黄油，雌激素和叶酸。根据体重增加，生化参数和组织病理学评估雌激素和叶酸的抗动脉粥样硬化作用。结果：B组的体重增加最高（PPPP <0.001）。在组织病理学研究中，黄油处理组的主动脉显示衬里内皮脱落，主动脉壁厚度增加和中膜内膜完整性丧失。与正常饮食相比，它还显示了在食用黄油的动物模型中肝脏的脂肪变化。结论：补充20％的黄油将能够引起血脂升高，并在主动脉和肝脏产生退行性变化，补充黄油的饮食中添加雌激素或叶酸可以抵消这种不良影响。

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