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首页> 外文期刊>BMC Microbiology >Protein secretion systems in bacterial-host associations, and their description in the Gene Ontology
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Protein secretion systems in bacterial-host associations, and their description in the Gene Ontology

机译：细菌-宿主关联中的蛋白质分泌系统及其在基因本体论中的描述

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Protein secretion plays a central role in modulating the interactions of bacteria with their environments. This is particularly the case when symbiotic bacteria (whether pathogenic, commensal or mutualistic) are interacting with larger host organisms. In the case of Gram-negative bacteria, secretion requires translocation across the outer as well as the inner membrane, and a diversity of molecular machines have been elaborated for this purpose. A number of secreted proteins are destined to enter the host cell (effectors and toxins), and thus several secretion systems include apparatus to translocate proteins across the plasma membrane of the host also. The Plant-Associated Microbe Gene Ontology (PAMGO) Consortium has been developing standardized terms for describing biological processes and cellular components that play important roles in the interactions of microbes with plant and animal hosts, including the processes of bacterial secretion. Here we survey bacterial secretion systems known to modulate interactions with host organisms and describe Gene Ontology terms useful for describing the components and functions of these systems, and for capturing the similarities among the diverse systems.
机译：蛋白质分泌在调节细菌与其环境的相互作用中起着核心作用。当共生细菌（无论是致病的，共生的还是共生的）与较大的宿主生物相互作用时，情况尤其如此。在革兰氏阴性细菌的情况下，分泌需要穿过外膜和内膜，并且为此目的已经设计了多种分子机器。多种分泌的蛋白质注定要进入宿主细胞（效应子和毒素），因此，一些分泌系统包括使蛋白质也跨宿主质膜转运的装置。植物相关微生物基因本体论（PAMGO）联盟已经开发了标准化术语，用于描述生物过程和细胞成分，这些成分在微生物与植物和动物宿主（包括细菌分泌过程）的相互作用中起着重要作用。在这里，我们调查了已知能调节与宿主生物相互作用的细菌分泌系统，并描述了基因本体论术语，这些术语可用于描述这些系统的组成和功能，以及捕获各种系统之间的相似性。

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