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首页> 外文期刊>BMC Microbiology >Global transcriptional response of pig brain and lung to natural infection by Pseudorabies virus
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Global transcriptional response of pig brain and lung to natural infection by Pseudorabies virus

机译：猪脑和肺对伪狂犬病病毒自然感染的整体转录反应

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Pseudorabies virus (PRV) is an alphaherpesviruses whose native host is pig. PRV infection mainly causes signs of central nervous system disorder in young pigs, and respiratory system diseases in the adult. In this report, we have analyzed native host (piglets) gene expression changes in response to acute pseudorabies virus infection of the brain and lung using a printed human oligonucleotide gene set from Illumina. A total of 210 and 1130 out of 23,000 transcript probes displayed differential expression respectively in the brain and lung in piglets after PRV infection (p-value 0.01), with most genes displaying up-regulation. Biological process and pathways analysis showed that most of the up-regulated genes are involved in cell differentiation, neurodegenerative disorders, the nervous system and immune responses in the infected brain whereas apoptosis, cell cycle control, and the mTOR signaling pathway genes were prevalent in the infected lung. Additionally, a number of differentially expressed genes were found to map in or close to quantitative trait loci for resistance/susceptibility to pseudorabies virus in piglets. This is the first comprehensive analysis of the global transcriptional response of the native host to acute alphaherpesvirus infection. The differentially regulated genes reported here are likely to be of interest for the further study and understanding of host viral gene interactions.
机译：伪狂犬病病毒（PRV）是一种α疱疹病毒，其天然宿主为猪。 PRV感染主要引起幼猪中枢神经系统疾病的迹象，以及成年猪呼吸系统疾病。在此报告中，我们使用了从Illumina印刷的人类寡核苷酸基因集，分析了响应于脑和肺的急性伪狂犬病毒感染的天然宿主（小猪）基因表达变化。 PRV感染后，在23,000个转录本探针中，总共210个和1130个分别在仔猪的脑和肺中显示差异表达（p值<0.01），大多数基因显示上调。生物学过程和途径分析表明，大多数上调的基因与受感染的大脑中的细胞分化，神经退行性疾病，神经系统和免疫反应有关，而凋亡，细胞周期控制和mTOR信号通路基因在该病中很普遍。肺部感染。另外，发现了许多差异表达的基因在小猪中对伪狂犬病病毒的抗性/易感性中或接近于定量性状基因座。这是对宿主对急性α疱疹病毒感染的全球转录反应的首次全面分析。此处报道的差异调节基因可能是进一步研究和了解宿主病毒基因相互作用的兴趣所在。

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