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首页> 外文期刊>British Biotechnology Journal >Efficacy of Ascorbic Acid in Reducing Glyphosate-Induced Toxicity in Rats
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Efficacy of Ascorbic Acid in Reducing Glyphosate-Induced Toxicity in Rats

机译：抗坏血酸对降低草甘膦诱导的大鼠毒性的作用

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Aim: Humans and animals interact with their environments on a daily basis and, as a consequence, are exposed to a broad spectrum of synthesized chemicals present in the food they eat, the air they breathe and the water they drink including glyphosate. This study was aimed at investigating the effects of glyphosate on the sperm dynamics of male albino rats and the protective effects of ascorbic acid. Methods: Twenty five mature male albino rats were weighed and divided into five groups in a completely randomized design (CRD). Group 1 rats served as the control. Rats in groups 2 and 4 received 250ml/kg and 500ml/kg of glyphosate while groups 3 and 5 rats were administered with 250ml/kg and 500ml/kg of glyphosate and 200mg/kg of ascorbic acid, respectively, which were administered orally using oral gavages. The treatment regimen lasted for 65 days. Results: Our results showed that there were significant adverse effects (P<0.05) of glyphosate treatment on sperm parameters and the cyto-architecture of the gonad, which showed disruption in the seminiferous tubules, necrotic germinal epithelium and clumped Leydig cells. However, administering the rats with ascorbic acid caused significant ameliorating effects on the parameters investigated. Conclusion: Succinctly, glyphosate exposure to animals is detrimental to their reproductive physiology, including the cellular integrity of the gonads. This not notwithstanding, administering the affected animals with ascorbic acids might reduce the toxicity inflicted by the glyphosate.
机译：目的：人与动物每天与环境互动，结果使它们接触到所吃食物，呼吸空气和饮用的水（包括草甘膦）中存在的多种合成化学物质。本研究旨在探讨草甘膦对雄性白化病大鼠精子动力学的影响以及抗坏血酸的保护作用。方法：称取25只成年雄性白化病成年大鼠，按完全随机设计（CRD）分为5组。第1组大鼠作为对照。第2组和第4组的大鼠分别接受250ml / kg和500ml / kg的草甘膦，而第3组和第5组的大鼠分别给予250ml / kg和500ml / kg的草甘膦和200mg / kg的抗坏血酸，分别口服管。该治疗方案持续了65天。结果：我们的结果表明，草甘膦处理对精子参数和性腺的细胞结构有明显的不良影响（P <0.05），这表明生精小管，坏死的生发上皮和成块的Leydig细胞受到破坏。但是，给大鼠服用抗坏血酸对所研究的参数产生了明显的改善作用。结论：简而言之，草甘膦接触动物有害于其生殖生理，包括性腺的细胞完整性。尽管如此，给患病动物施用抗坏血酸可能会降低草甘膦造成的毒性。

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