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首页> 外文期刊>BMC Microbiology >Temporal and spatial patterns of bovine Escherichia coli O157 prevalence and comparison of temporal changes in the patterns of phage types associated with bovine shedding and human E. coli O157 cases in Scotland between 1998-2000 and 2002-2004
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Temporal and spatial patterns of bovine Escherichia coli O157 prevalence and comparison of temporal changes in the patterns of phage types associated with bovine shedding and human E. coli O157 cases in Scotland between 1998-2000 and 2002-2004

机译：1998-2000年至2002-2004年苏格兰牛E.coli O157流行的时空格局以及与牛脱落和人E.coli O157病例相关的噬菌体类型的时空变化比较

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Background Escherichia coli O157 is an important cause of acute diarrhoea, haemorrhagic colitis and, especially in children, haemolytic uraemic syndrome (HUS). Incidence rates for human E. coli O157 infection in Scotland are higher than most other United Kingdom, European and North American countries. Cattle are considered the main reservoir for E. coli O157. Significant associations between livestock related exposures and human infection have been identified in a number of studies. Results Animal Studies: There were no statistically significant differences (P = 0.831) in the mean farm-level prevalence between the two studies (SEERAD: 0.218 (95%CI: 0.141-0.32); IPRAVE: 0.205 (95%CI: 0.135-0.296)). However, the mean pat-level prevalence decreased from 0.089 (95%CI: 0.075-0.105) to 0.040 (95%CI: 0.028-0.053) between the SEERAD and IPRAVE studies respectively (P P Human Cases: Contrasting the same time periods, there was a decline in the overall comparative annual reported incidence of human cases as well as in all the major PT groups except 'Other' PTs. For both cattle and humans, the predominant phage type between 1998 and 2004 was PT21/28 comprising over 50% of the positive cattle isolates and reported human cases respectively. The proportion of PT32, however, was represented by few (P = 0.002). Conclusion There was no significant decrease in the mean farm-level prevalence of E. coli O157 between 1998 and 2004 in Scotland, despite significant declines in mean pat-level prevalence. Although there were declines in the number of human cases between the two study periods, there is no statistically significant evidence that the overall rate (per 100,000 population) of human E. coli O157 infections in Scotland over the last 10 years has altered. Comparable patterns in the distribution of PTs 21/28 and 32 between cattle and humans support a hypothesized link between the bovine reservoir and human infections. This emphasizes the need to apply and improve methods to reduce bovine shedding of E. coli O157 in Scotland where rates appear higher in both cattle and human populations, than in other countries.
机译：背景技术大肠杆菌O157是引起急性腹泻，出血性结肠炎，尤其是儿童溶血性尿毒症（HUS）的重要原因。在苏格兰，人类O157大肠杆菌感染的发生率高于其他大多数英国，欧洲和北美国家。牛被认为是大肠杆菌O157的主要蓄水池。在许多研究中已经确定了与牲畜有关的接触与人类感染之间的重要关联。结果动物研究：两项研究（SEERAD：0.218（95％CI：0.141-0.32）; IPRAVE：0.205（95％CI：0.135-）之间，平均农场水平患病率无统计学差异（P = 0.831）。 0.296））。但是，在SEERAD和IPRAVE研究之间，平均拍子患病率分别从0.089（95％CI：0.075-0.105）降低至0.040（95％CI：0.028-0.053）（PP人类病例：在相同时间段内，是人类和所有其他主要PT组（“其他” PTs除外）的总体年度比较报告发病率下降的情况。对于牛和人，1998年至2004年之间主要的噬菌体类型为PT21 / 28，占50％以上结论PT32的阳性分离株和报告的人类病例分别为PT3和PT32的比例很小（P = 0.002）结论1998年至2004年间，大肠杆菌O157的平均农场水平流行率没有显着降低在苏格兰，尽管平均拍拍水平患病率显着下降，尽管两个研究期之间的人类病例数有所下降，但没有统计学上显着的证据表明人大肠杆菌O的总体发生率（每10万人口）在过去的10年中，苏格兰有157例感染发生了变化。牛和人之间PT 21/28和PT 32分布的可比模式支持了牛水库与人类感染之间的假设联系。这强调了需要应用和改进方法来减少苏格兰O157大肠杆菌的牛脱落，在苏格兰，牛和人类的比率都高于其他国家。

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