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首页> 外文期刊>BMC Microbiology >Association of the shuffling of Streptococcus pyogenes clones and the fluctuation of scarlet fever cases between 2000 and 2006 in central Taiwan
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Association of the shuffling of Streptococcus pyogenes clones and the fluctuation of scarlet fever cases between 2000 and 2006 in central Taiwan

机译：2000-2006年台湾中部化脓性链球菌克隆改组与猩红热病例波动的关系。

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Background The number of scarlet fever occurrences reported between 2000 and 2006 fluctuated considerably in central Taiwan and throughout the nation. Isolates of Streptococcus pyogenes were collected from scarlet fever patients in central Taiwan and were characterized by emm sequencing and a standardized pulsed-field gel electrophoresis (PFGE) method. National weekly report data were collected for investigating epidemiological trends. Results A total of 23 emm types were identified in 1,218 S. pyogenes isolates. The five most prevalent emm types were emm12 (50.4%), emm4 (23.2%), emm1 (16.4%), emm6 (3.8%) and emm22 (3.0%). PFGE analysis with SmaI suggested that, with a few exceptions, strains with a common emm type belonged to the same clone. There were two large emm12 clones, one with DNA resistant to cleavage by SmaI. Each prevalent emm clone had major PFGE strain(s) and many minor strains. Most of the minor strains emerged in the population and disappeared soon after. Even some major strains remained prevalent for only 2–3 years before declining. The large fluctuation of scarlet fever cases between 2000 and 2006 was associated with the shuffling of six prevalent emm clones. In 2003, the dramatic drop in scarlet fever cases in central Taiwan and throughout the whole country was associated with the occurrence of a severe acute respiratory syndrome (SARS) outbreak that occurred between late-February and mid-June in Taiwan. Conclusion The occurrences of scarlet fever in central Taiwan in 2000–2006 were primarily caused by five emm types, which accounted for 96.8% of the isolates collected. Most of the S. pyogenes strains (as defined by PFGE genotypes) emerged and lasted for only a few years. The fluctuation in the number of scarlet fever cases during the seven years can be primarily attributed to the shuffling of six prevalent emm clones and to the SARS outbreak in 2003.
机译：背景技术2000年至2006年期间，在台湾中部和全国各地报告的猩红热发生数量有很大波动。化脓性链球菌的分离物来自台湾中部的猩红热患者，并通过电子测序和标准化脉冲场凝胶电泳（PFGE）方法进行了表征。收集国家每周报告数据以调查流行病学趋势。结果在1,218个化脓性链球菌中共鉴定出23种emm类型。五个最普遍的emm类型是emm12（50.4％），emm4（23.2％），emm1（16.4％），emm6（3.8％）和emm22（3.0％）。使用SmaI进行的PFGE分析表明，除少数例外，具有相同emm类型的菌株属于同一克隆。有两个大的emm12克隆，一个克隆具有抗SmaI切割的DNA。每个流行的emm克隆都有主要的PFGE菌株和许多次要的菌株。大多数次要菌株出现在种群中，并在不久后消失。甚至一些主要毒株在下降之前仅流行了2-3年。 2000年至2006年期间，猩红热病例的大幅波动与六个流行的emm克隆的改组有关。 2003年，台湾中部和全国各地的猩红热病例急剧减少与2月下旬至6月中旬在台湾发生的严重急性呼吸道综合症（SARS）爆发有关。结论2000-2006年台湾中部猩红热的发生主要是由5种emm类型引起的，占所收集菌株的96.8％。化脓性链球菌的大多数菌株（由PFGE基因型定义）仅持续了几年。七年来猩红热病例数量的波动主要归因于六个流行的emm克隆的改组和2003年SARS的爆发。

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