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首页> 外文期刊>Breast Cancer: Targets and Therapy >Dormancy in breast cancer
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Dormancy in breast cancer

机译：乳腺癌的休眠

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Abstract: Tumor dormancy describes a prolonged quiescent state in which tumor cells are present, but disease progression is not yet clinically apparent. Breast cancer is especially known for long asymptomatic periods, up to 25 years, with no evidence of the disease, followed by a relapse. Factors that determine the cell's decision to enter a dormant state and that control its duration remain unclear. In recent years, considerable progress has been made in understanding how tumor cells circulating in the blood interact and extravasate into secondary sites and which factors might determine whether these cells survive, remain dormant, or become macrometastases. The mechanisms of tumor cell dormancy are still not clear. Two different hypotheses are currently discussed: tumor cells persist either by completely withdrawing from the cell cycle or by continuing to proliferate at a slow rate that is counterbalanced by cell death. Because dormant disseminated tumor cells may be the founders of metastasis, one hypothesis is that dormant tumor cells, or at least a fraction of them, share stem cell-like characteristics that may be responsible for their long half-lives and their suggested resistance to standard chemotherapy. Therefore, knowledge of the biology of tumor cell dormancy may be the basis from which to develop innovative targeted therapies to control or eliminate this tumor cell fraction. In this review, we discuss biological mechanisms and clinical implications of tumor dormancy in breast cancer patients.
机译：摘要：肿瘤休眠描述了其中存在肿瘤细胞的长期静止状态，但是疾病进展在临床上尚不明显。乳腺癌以无症状的最长症状（长达25年）而著称，没有这种疾病的证据，随后复发。决定电池进入休眠状态并控制其持续时间的因素尚不清楚。近年来，在了解血液中循环的肿瘤细胞如何相互作用并扩散到继发部位以及哪些因素可能决定这些细胞是否存活，保持休眠或变为巨转移灶方面取得了长足进展。肿瘤细胞休眠的机制仍不清楚。当前讨论了两种不同的假说：肿瘤细胞通过完全退出细胞周期或以缓慢的速度继续增殖而持续存在，而这种缓慢的速度可被细胞死亡所抵消。由于休眠的弥散性肿瘤细胞可能是转移的始作俑者，因此一个假设是，休眠的肿瘤细胞（或至少其中一部分）具有类似干细胞的特征，这可能是其半衰期长和建议的对标准抗性的原因化学疗法。因此，肿瘤细胞休眠生物学的知识可能是开发创新的靶向疗法以控制或消除该肿瘤细胞部分的基础。在这篇综述中，我们讨论了乳腺癌患者中肿瘤休眠的生物学机制和临床意义。

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