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首页> 外文期刊>British Biotechnology Journal >Genetic and Phenotypic Identification ofVancomycin-Resistant Staphylococcus aureusIsolates from Retail Poultry Carcasses inOmu-Aran, North-Central Nigeria
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Genetic and Phenotypic Identification ofVancomycin-Resistant Staphylococcus aureusIsolates from Retail Poultry Carcasses inOmu-Aran, North-Central Nigeria

机译：尼日利亚中北部奥姆阿兰零售家禽尸体中耐万古霉素金黄色葡萄球菌分离株的遗传和表型鉴定

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摘要

Staphylococcus aureus is a well-known agent of zoonotic infections. Livestock-associated methicillin-resistant S. aureus (LA-MRSA) had been receiving public health attention for over a decade. Recently, the genomes of some MRSA strains evolved further by enabling acquisition of vanA gene from enterococcus which drives the emergence of vancomycin-resistant S. aureus (VRSA), thus signaling a higher threat to antimicrobial chemotherapy and diagnostic microbiology. This study was designed to examine slaughtered chicken carcasses in Omu-Aran, North-Central Nigeria for the presence of VRSA using vancomycin agar screen (VAS) as recommended by the Clinical and Laboratories Standards Institute (CLSI). To provide independent witness to further support the evidences from VAS, a 235 bp marker for vanA gene was simultaneously detected by PCR. From April 2013 through May 2014, chicken carcasses (n=784) were collected and studied. Among 155 (19.8%) samples which yielded S. aureus, VAS and vanA PCR methods unequivocally identified VRSA in 22 (14.2%). Compared with 46.2% VRSA report from Zaria, North-Western Nigeria, the incidence of VRSA is much less in Omu-Aran chicken carcasses than those of Zaria. Further investigation in other parts of Nigeria is recommended in order to generate nation-wide data on VRSA in this country.
机译：金黄色葡萄球菌是人畜共患病感染的众所周知的媒介。与牲畜相关的耐甲氧西林金黄色葡萄球菌（LA-MRSA）受到公众健康的关注已有十多年了。最近，一些MRSA菌株的基因组通过允许从肠球菌中获得vanA基因而进一步进化，该基因驱动了耐万古霉素的金黄色葡萄球菌（VRSA）的出现，从而标志着对抗菌化学疗法和诊断微生物学的更高威胁。这项研究旨在按照临床和实验室标准协会（CLSI）的建议，使用万古霉素琼脂筛查（VAS）检查尼日利亚北部中部Omu-Aran屠宰的鸡的尸体中是否存在VRSA。为了提供独立的证人进一步支持VAS的证据，通过PCR同时检测到了235 bp的vanA基因标记。从2013年4月到2014年5月，收集并研究了鸡尸体（n = 784）。在155个（19.8％）产生金黄色葡萄球菌的样品中，VAS和vanA PCR方法明确鉴定了22个（14.2％）中的VRSA。与尼日利亚西北部Zaria的VRSA报告的46.2％相比，Omu-Aran鸡car体中VRSA的发生率比Zaria少得多。建议在尼日利亚其他地区进行进一步调查，以生成有关该国VRSA的全国性数据。

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