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首页> 外文期刊>BMC Microbiology >A phylogenetic group of Escherichia coli associated with active left-sided Inflammatory Bowel Disease
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A phylogenetic group of Escherichia coli associated with active left-sided Inflammatory Bowel Disease

机译：与活动性左侧炎症性肠病相关的大肠埃希氏菌的系统发生群

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Background Escherichia coli have been found in increased numbers in tissues from patients with Inflammatory Bowel Disease (IBD) and adherent-invasive E. coli have been found in resected ileum from patients with Crohn's disesae. This study aimed to characterize possible differences in phylogenetic group (triplex PCR), extraintestinal pathogenic E. coli (ExPEC) genes and multilocus sequence type (MLST) between E. coli strains isolated from IBD patients with past or present involvement of the left side of the colon and from controls. Results Fecal samples were collected from 18 patients and from 10 healthy controls. Disease activity was evaluated by sigmoidoscopy. Interestingly, E. coli strains of the phylogenetic group B2 were cultured from 60% of patients with IBD compared to 11% of healthy controls (p E. coli B2 strains with at least one positive ExPEC gene among different groups, 86% were found positive among active IBD patients, significantly more than 13% among inactive IBD patients (p E. coli strains associated with active compared to inactive IBD was achieved. Conclusion In conclusion, E. coli of the phylogenetic group B2 were isolated more frequently from IBD patients with past or present involvement of the left side of the colon compared to healthy controls, and B2 strains with ExPEC genes were found more frequently among IBD patients with active disease compared to patients with inactive disease.
机译：背景技术在患有炎症性肠病（IBD）的患者的组织中发现大肠杆菌的数量增加，并且在患有克罗恩病的患者的切除的回肠中发现了粘附侵入性大肠杆菌。这项研究旨在表征从过去或现在涉及左侧左侧或右侧感染的IBD患者分离的大肠杆菌菌株之间的系统发育组（三重PCR），肠外致病性大肠杆菌（ExPEC）基因和多基因座序列类型（MLST）的可能差异。结肠和对照。结果从18例患者和10例健康对照中收集粪便样品。通过乙状结肠镜检查评估疾病活动。有趣的是，从60％的IBD患者中培养了系统发育B2型大肠杆菌菌株，而健康对照组则为11％（不同组中的p E. coli B2菌株至少具有一个阳性ExPEC基因，其中86％呈阳性）在活动性IBD患者中，非活动性IBD患者中显着超过13％（与活动性IBD相比，与活动性相关的大肠埃希菌菌株。）结论：系统发育组B2的大肠杆菌从IBD患者中分离的频率更高。与健康对照相比，过去或现在结肠左侧受累的情况更为明显，在患有活动性疾病的IBD患者中，与具有非活动性疾病的患者相比，发现具有ExPEC基因的B2菌株更为频繁。

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