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首页> 外文期刊>British Biotechnology Journal >In vitro Pharmacological Investigations ofUsing Leaf Callus Extracts of Canthiumparviflorum Lam
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In vitro Pharmacological Investigations ofUsing Leaf Callus Extracts of Canthiumparviflorum Lam

机译：小菜蛾叶片愈伤组织提取物的体外药理研究

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Aims: The Canthium parviflorum Lam. is an important medicinal plant extensively used in traditional oriental herbal medicines. It is important to screen for the novel biological activities and novel chemical constituents to further validate the use of this plant extract. This was mainly intended to screen in vitro pharmacological activities with callus extracts of Canthium parviflorum. Experiments were designed according to the standard methods and processes.Place and Duration of Study: The Pharmacology Department of Laila Research Centre in Vijayawada, Andhra Pradesh, India between September-October 2012.Methodology: Callus was induced from leaf explants of Canthium parviflorum on MS medium supplemented with 2,4-Dichlorophenoxyacetic acid and the compounds were extracted from dried callus using methanol solvent with Soxhlet apparatus.Results: The Graph pad Prism Version"‘5 software was used to analyze data in the form of figures. The callus extract was potentially inhibited the 5- Lipoxygenase inhibitory enzyme at significantly less IC50 value that was comparable with the standard drug inhibition. In addition, this extract was exhibited remarkable cytotoxicity with less LC50 value. However, this callus extract was shown very low potency in inhibiting the enzymes of acetyl cholinesterase, tyrosinase, alpha-glucosidase.Conclusion: The study demonstrated that callus extract of Canthium parviflorum shown more potent inhibition of 5-LOX and also remarkable cytotoxicity to be further screened for in vivo anticancer and anti-inflammatory activity.
机译：目的：小菜蛾（Canthium parviflorum Lam）。是广泛用于传统东方草药的重要药用植物。重要的是筛选新的生物活性和新的化学成分，以进一步验证该植物提取物的用途。这主要是为了筛选细小芸豆的愈伤组织提取物的体外药理活性。根据标准方法和过程设计实验。研究地点和持续时间：2012年9月至10月之间，印度安得拉邦维杰亚瓦达莱拉研究中心药理学系。方法：从小苍兰的叶片外植体上用MS诱导愈伤组织结果表明：使用Graph pad Prism Version“'5软件以图形形式分析数据。愈伤组织提取物为Soxhlet提取液。可以抑制5-脂氧合酶的抑制酶，其IC50值明显低于标准药物抑制水平;此外，该提取物表现出显着的细胞毒性，LC50值较低;但是，该愈伤组织提取物抑制酶的功效非常低乙酰胆碱酯酶，酪氨酸酶，α-葡萄糖苷酶的检测。细小Cancanium parviflorum束显示出对5-LOX的更强抑制作用，并且还具有显着的细胞毒性，可进一步筛选其体内抗癌和抗炎活性。

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