Impact of statin therapy on mortality in patients with sepsis-associated acute respiratory distress syndrome (ARDS) depends on ARDS severity: a prospective observational cohort study

Ashham Mansur; Maximilian Steinau; Aron Frederik Popov; Michael Ghadimi; Tim Beissbarth; Martin Bauer; José Hinz

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Impact of statin therapy on mortality in patients with sepsis-associated acute respiratory distress syndrome (ARDS) depends on ARDS severity: a prospective observational cohort study

机译：他汀类药物治疗对败血症相关性急性呼吸窘迫综合征（ARDS）患者死亡率的影响取决于ARDS严重程度：一项前瞻性观察性队列研究

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Background Previous investigations have presumed a potential therapeutic effect of statin therapy in patients with acute respiratory distress syndrome (ARDS). Statins are expected to attenuate inflammation in the lungs of patients with ARDS due to their anti-inflammatory effects. Clinical investigations of the role of statin therapy have revealed contradictory results. This study aimed to investigate whether pretreatment and continuous therapy with statins in patients with sepsis-associated ARDS are associated with 28-day survival according to disease severity (mild, moderate, or severe).

机译：背景技术先前的研究推测他汀类药物治疗对急性呼吸窘迫综合征（ARDS）有潜在的治疗作用。他汀类药物因其抗炎作用，有望减轻ARDS患者肺部的炎症。他汀类药物治疗作用的临床研究显示出矛盾的结果。这项研究的目的是根据疾病的严重程度（轻度，中度或重度）调查败血症相关性ARDS患者的他汀类药物的预处理和持续治疗是否与28天生存率相关。

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《BMC Medicine》 |2015年第1期|共页
作者
Ashham Mansur; Maximilian Steinau; Aron Frederik Popov; Michael Ghadimi; Tim Beissbarth; Martin Bauer; José Hinz;
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中图分类医药、卫生;
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1. Aspirin therapy in patients with acute respiratory distress syndrome (ARDS) is associated with reduced intensive care unit mortality: a prospective analysis [J] . Andrew J Boyle, Stefania Di Gangi, Umar I Hamid, Critical care : . 2015,第1期

机译：急性呼吸窘迫综合征（ARDS）患者的阿司匹林治疗与重症监护病房死亡率降低相关：前瞻性分析
2. Aspirin therapy in patients with acute respiratory distress syndrome (ARDS) is associated with reduced intensive care unit mortality: a prospective analysis [J] . Andrew J Boyle, Stefania Di Gangi, Umar I Hamid, Critical care : . 2015,第1期

机译：急性呼吸窘迫综合征（ARDS）患者的阿司匹林治疗与重症监护病房死亡率降低相关：前瞻性分析
3. Nucleated red blood cells as predictors of mortality in patients with acute respiratory distress syndrome (ARDS): an observational study [J] . Mario Menk, Lena Giebelh?user, Gerald Vorderwülbecke, Annals of Intensive Care . 2018,第1期

机译：急性呼吸窘迫综合征（ARDS）患者的有核红细胞可作为死亡率的预测指标：一项观察性研究
4. Modeling and Simulation of Respiratory System for Acute Respiratory Distress Syndrome (ARDS) Associated with COVID-19 [C] . Mohamed Elnoby Awad, Ahmed M. El-Garhy, Mohamed A. Eldosoky, National Radio Science Conference . 2021

机译：与Covid-19相关的急性呼吸窘迫综合征（ARDS）呼吸系统的建模与仿真
5. Nursing sensitive process and outcome measures in patients with adult respiratory distress syndrome (ARDS) receiving mechanical ventilation. [D] . Jones, Terry Lynn. 2004

机译：成人接受机械通气的呼吸窘迫综合征（ARDS）患者的护理敏感过程和结局指标。
6. Impact of statin therapy on mortality in patients with sepsis-associated acute respiratory distress syndrome (ARDS) depends on ARDS severity: a prospective observational cohort study [O] . Ashham Mansur, Maximilian Steinau, Aron Frederik Popov, 2015

机译：他汀类药物治疗对败血症相关性急性呼吸窘迫综合征（ARDS）患者死亡率的影响取决于ARDS严重程度：一项前瞻性观察性队列研究
7. Impact of statin therapy on mortality in patients with sepsis-associated acute respiratory distress syndrome (ARDS) depends on ARDS severity: a prospective observational cohort study [O] . Ashham Mansur, Maximilian Steinau, Aron Frederik Popov, 2015

机译：他汀类药物治疗对败血症相关性急性呼吸窘迫综合征（ARDS）患者死亡率的影响取决于ARDS严重程度：一项前瞻性观察性队列研究

Impact of statin therapy on mortality in patients with sepsis-associated acute respiratory distress syndrome (ARDS) depends on ARDS severity: a prospective observational cohort study

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