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首页> 外文期刊>BMC Microbiology >Gene Ontology annotation highlights shared and divergent pathogenic strategies of type III effector proteins deployed by the plant pathogen Pseudomonas syringae pv tomato DC3000 and animal pathogenic Escherichia coli strains
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Gene Ontology annotation highlights shared and divergent pathogenic strategies of type III effector proteins deployed by the plant pathogen Pseudomonas syringae pv tomato DC3000 and animal pathogenic Escherichia coli strains

机译：基因本体论注释突出显示了由植物病原体丁香假单胞菌PV番茄DC3000和动物病原性大肠杆菌菌株部署的III型效应蛋白的共有和不同的致病策略

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摘要

Genome-informed identification and characterization of Type III effector repertoires in various bacterial strains and species is revealing important insights into the critical roles that these proteins play in the pathogenic strategies of diverse bacteria. However, non-systematic discipline-specific approaches to their annotation impede analysis of the accumulating wealth of data and inhibit easy communication of findings among researchers working on different experimental systems. The development of Gene Ontology (GO) terms to capture biological processes occurring during the interaction between organisms creates a common language that facilitates cross-genome analyses. The application of these terms to annotate type III effector genes in different bacterial species - the plant pathogen Pseudomonas syringae pv tomato DC3000 and animal pathogenic strains of Escherichia coli - illustrates how GO can effectively describe fundamental similarities and differences among different gene products deployed as part of diverse pathogenic strategies. In depth descriptions of the GO annotations for P. syringae pv tomato DC3000 effector AvrPtoB and the E. coli effector Tir are described, with special emphasis given to GO capability for capturing information about interacting proteins and taxa. GO-highlighted similarities in biological process and molecular function for effectors from additional pathosystems are also discussed.
机译：通过基因组信息识别和表征各种细菌菌株和物种中的III型效应子库，正揭示出这些蛋白质在多种细菌的致病策略中所起的关键作用的重要见解。但是，非系统性的学科特定方法对其进行注解会阻碍对积累的数据的分析，并会妨碍在不同实验系统上工作的研究人员之间轻松地传达发现结果。开发用于捕获生物之间相互作用期间发生的生物过程的基因本体论（GO）术语创造了有助于跨基因组分析的通用语言。这些术语在不同细菌种类（植物病原体丁香假单胞菌pv番茄DC3000和大肠杆菌的动物病原体）中注释III型效应子基因的应用说明了GO如何有效描述作为基因组成部分的不同基因产物之间的基本相似性和差异。多种致病策略。在丁香假单胞菌pv番茄DC3000效应子AvrPtoB和大肠杆菌效应子Tir的GO注释的深入描述中，特别强调了GO捕获与相互作用蛋白和分类单元有关的信息的能力。 GO还讨论了其他病理系统的效应器在生物学过程和分子功能方面的相似性。

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