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首页> 外文期刊>BMC Microbiology >Effects of prophylactic administration of bacteriophages to immunosuppressed mice infected with Staphylococcus aureus
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Effects of prophylactic administration of bacteriophages to immunosuppressed mice infected with Staphylococcus aureus

机译：预防性使用噬菌体对金黄色葡萄球菌感染的免疫抑制小鼠的影响

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Background Bacteriophages can be successfully applied to treat infections caused by antibiotic-resistant bacteria. Until now no attempts have been undertaken to treat infections in immunosuppressed patients with phages. In this work we investigated the prophylactic efficacy of specific bacteriophages in CBA mice treated with cyclophosphamide (CP) and infected with Staphylococcus aureus. Results High numbers of bacterial colony-forming units in the organs as well as elevated tumor necrosis factor and interleukin-6 serum concentrations in CP-treated and S. aureus-infected mice were significantly lowered upon application of phages. The phages markedly increased the percentage of circulating neutrophils and immature cells from the myelocytic and lymphocytic lineages in CP-treated, S. aureus-infected mice as well as of myelocytes and immature neutrophils in the bone marrow. In addition, phages stimulated in such mice generation of specific agglutinins against S. aureus. Conclusion Application of specific phages to immunosuppressed mice prior to infection with S. aureus proved very effective, suggesting a potential benefit of phage therapy in immunocompromised patients experiencing bacterial infections.
机译：背景噬菌体可以成功地用于治疗由抗药性细菌引起的感染。迄今为止，尚未尝试治疗免疫抑制的噬菌体患者的感染。在这项工作中，我们调查了特定的噬菌体在用环磷酰胺（CP）处理并感染金黄色葡萄球菌的CBA小鼠中的预防效力。结果应用噬菌体后，经CP处理的和经金黄色葡萄球菌感染的小鼠的器官中大量细菌菌落形成单位数量增加，肿瘤坏死因子和白细胞介素6血清浓度升高，均明显降低。噬菌体显着增加了经CP治疗的金黄色葡萄球菌感染小鼠的骨髓和淋巴细胞系中循环中性粒细胞和未成熟细胞的百分比，以及骨髓中骨髓细胞和未成熟中性粒细胞的百分比。另外，在这种小鼠中刺激的噬菌体产生针对金黄色葡萄球菌的特异性凝集素。结论在金黄色葡萄球菌感染之前将特异性噬菌体应用于免疫抑制的小鼠非常有效，这表明噬菌体疗法对遭受细菌感染的免疫受损患者具有潜在的益处。

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