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首页> 外文期刊>BMC Microbiology >Clonal dissemination of the multi-drug resistant Salmonella enterica serovar Braenderup, but not the serovar Bareilly, of prevalent serogroup C1 Salmonella from Taiwan
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Clonal dissemination of the multi-drug resistant Salmonella enterica serovar Braenderup, but not the serovar Bareilly, of prevalent serogroup C1 Salmonella from Taiwan

机译：来自台湾的流行血清群C1沙门氏菌的多药耐药肠炎沙门氏菌Braenderup的克隆传播，但不传播Bareilly血清

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Background Nontyphoidal Salmonella is the main cause of human salmonellosis. In order to study the prevalent serogroups and serovars of clinical isolates in Taiwan, 8931 Salmonellae isolates were collected from 19 medical centers and district hospitals throughout the country from 2004 to 2007. The pulsed-field eletrophoresis types (PFGE) and antibiotic resistance profiles of Salmonella enterica serovars Bareilly (S. Bareilly) and Braenderup (S. Braenderup) were compared, and multi-drug resistance (MDR) plasmids were characterized. Results Over 95% of human salmonellosis in Taiwan was caused by five Salmonella serogroups: B, C1, C2-C3, D1, and E1. S. Typhymurium, S. Enteritidis, S. Stanley and S. Newport were the four most prevalent serovars, accounting for about 64% of isolates. While only one or two major serovars from four of the most prevalent serogroups were represented, four predominant serovars were found in serogroup C1 Salmonellae. The prevalence was decreasing for S. Choleraeuis and S. Braenderup, and S. Virchow and increasing for S. Bareilly. S. Braenderup mainly caused gastroenteritis in children; in contrast, S. Bareiley infected children and elderly people. Both serovars differed by XbaI-PFGE patterns. Almost all S. Bareilly isolates were susceptible to antibiotics of interest, while all lacked plasmids and belonged to one clone. Two distinct major clones in S. Braenderup were cluster A, mainly including MDR isolates with large MDR plasmid from North Taiwan, and cluster B, mainly containing susceptible isolates without R plasmid from South Taiwan. In cluster A, there were two types of conjugative R plasmids with sizes ranging from 75 to 130 kb. Type 1 plasmids consisted of replicons F1A/F1B, blaTEM, IS26, and a class 1 integron with the genes dfrA12-orfF-aadA2-qacEΔ1-sulI. Type 2 plasmids belonged to incompatibility group IncI, contained tnpA-blaCMY-2-blc-sugE genetic structures and lacked both IS26 and class 1 integrons. Although type 2 plasmids showed higher conjugation capability, type 1 plasmids were the predominant plasmid. Conclusions Serogroups B, C1, C2-C3, D1, and E1 of Salmonella caused over 95% of human salmonellosis. Two prevalent serovars within serogroup C1, S. Bareilly and cluster B of S. Braenderup, were clonal and drug-susceptible. However, cluster A of S. Braenderup was MDR and probably derived from susceptible isolates by acquiring one of two distinct conjugative R plasmids.
机译：背景非伤寒沙门氏菌是人类沙门氏菌病的主要原因。为了研究台湾临床分离株的流行血清型和血清型，从2004年至2007年从全国19个医疗中心和地区医院收集了8931株沙门氏菌。沙门氏菌的脉冲场电泳类型（PFGE）和抗生素耐药性谱比较了肠球菌Bareilly（S. Bareilly）和Braenderup（S. Braenderup），并鉴定了多药耐药性（MDR）质粒。结果台湾超过95％的人类沙门氏菌病是由五个沙门氏菌血清群引起的：B，C1，C2-C3，D1和E1。鼠伤寒沙门氏菌，肠炎沙门氏菌，斯坦利链霉菌和纽波特菌是最流行的四种血清型，约占分离株的64％。虽然仅代表了四个最普遍的血清群中的一两个主要血清型，但在血清群C1沙门氏菌中却发现了四个主要的血清型。 S. Choleraeuis和S. Braenderup和S. Virchow的患病率下降，而S. Bareilly的患病率上升。 S. Braenderup主要引起儿童肠胃炎;相反，S。Bareiley感染了儿童和老年人。两种血清型都因XbaI-PFGE模式而异。几乎所有巴雷利链球菌的分离株都对目标抗生素敏感，而所有分离株均缺乏质粒，属于一个克隆。 S. Braenderup中两个不同的主要克隆是簇A，主要包括来自台湾北部的带有大型MDR质粒的MDR分离株，以及簇B，主要含有来自台湾南部的无R质粒的易感分离株。在簇A中，有两种类型的结合性R质粒，大小在75至130 kb之间。 1型质粒由复制子F1A / F1B，bla TEM ，IS26和具有基因dfrA12-orfF-aadA2-qacEΔ1-sulI的1类整合子组成。 2型质粒属于不相容性组IncI，含有tnpA-bla CMY-2 -blc-sugE遗传结构，并且缺少IS26和1类整合素。尽管2型质粒显示较高的结合能力，但1型质粒是主要质粒。结论沙门氏菌的血清群B，C1，C2-C3，D1和E1导致超过95％的人类沙门氏菌病。 C1血清群中的两个流行血清型分别为S. Bareilly和S. Braenderup的B群，是克隆性和药物敏感性的。但是，S。Braenderup的簇A是MDR，可能是通过获取两个不同的共轭R质粒之一从易感菌株中分离得到的。

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