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首页> 外文期刊>BMC Neuroscience >BDNF Val66Met polymorphism and protein levels in Amniotic Fluid
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BDNF Val66Met polymorphism and protein levels in Amniotic Fluid

机译：羊水中的BDNF Val66Met多态性和蛋白质水平

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Background Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin which plays survival- and growth-promoting activity in neuronal cells and it is involved in cellular plasticity mechanisms as it controls activity dependent synaptic transmission. A functional polymorphism (Val66Met) in the pro-region of BDNF, which affects the intracellular trafficking of proBDNF has been associated with memory and cognitive deficits as well as to an increased susceptibility for several psychiatric disorders especially those with a neurodevelopmental origin. To date, no study has evaluated the influence of the Val66Met polymorphism on BDNF levels in a peripheral system that may reflect fetal neurodevelopment. Therefore we investigated in amniotic fluids (AF) obtained from 139 healthy women during 15-17 week of pregnancy, BDNF protein levels in correlation with the Val66Met polymorphism. Results Interestingly we found a significant BDNF protein levels reduction in 55 Met carriers (Val/Met and Met/Met) (p = 0.002) as compared to 84 non carriers (Val/Val), and no effect of fetus gender, maternal age or gestation week on BDNF levels has been observed. Conclusion These results, although explorative, indicate that during fetal life the Val66Met genotype might influences BDNF protein levels in AF supporting the involvement of this polymorphism in behavioral and functional brain individual differences in the adulthood.
机译：背景技术脑源性神经营养因子（BDNF）是一种神经营养蛋白，在神经元细胞中发挥生存和生长促进活性，并且由于其控制活动依赖性突触传递而参与细胞可塑性机制。 BDNF前区的功能多态性（Val66Met），会影响proBDNF的细胞内运输，与记忆和认知缺陷以及对多种精神疾病，尤其是神经发育起源的精神疾病的易感性有关。迄今为止，尚无研究评估Val66Met多态性对可能反映胎儿神经发育的外周系统中BDNF水平的影响。因此，我们调查了在妊娠15-17周期间从139名健康妇女中获得的羊水（AF）中，BDNF蛋白水平与Val66Met多态性相关。结果有趣的是，与84个非携带者（Val / Val）相比，我们发现55个Met携带者（Val / Met和Met / Met）的BDNF蛋白水平显着降低（p = 0.002），并且对胎儿性别，产妇年龄或已经观察到妊娠周的BDNF水平。结论这些结果尽管具有探索性，但表明在胎儿生命中，Val66Met基因型可能会影响房颤的BDNF蛋白水平，从而支持该多态性参与成年行为和功能性大脑个体差异。

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