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首页> 外文期刊>BMC Nephrology >Chronic kidney disease is associated with adverse outcomes among elderly patients taking clopidogrel after hospitalization for acute coronary syndrome
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Chronic kidney disease is associated with adverse outcomes among elderly patients taking clopidogrel after hospitalization for acute coronary syndrome

机译：慢性冠脉综合征住院后服用氯吡格雷的老年患者的慢性肾脏疾病与不良结局相关

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Background Chronic kidney disease (CKD) is associated with worse outcomes among patients with acute coronary syndrome (ACS). Less is known about the impact of CKD on longitudinal outcomes among clopidogrel treated patients following ACS. Methods Using a retrospective cohort design, we identified patients hospitalized with ACS between 10/1/2005 and 1/10/10 at Department of Veterans Affairs (VA) facilities and who were discharged on clopidogrel. Using outpatient serum creatinine values, estimated glomerular filtration rate [eGFR (1.73?ml/min/m2)] was calculated using the CKD-EPI equation. The association between eGFR and mortality, hospitalization for acute myocardial infarction (AMI), and major bleeding were examined using Cox proportional hazards models. Results Among 7413 patients hospitalized with ACS and discharged taking clopidogrel, 34.5% had eGFR 30–60 and 11.6% had eGFR??=60, individuals with eGFR 30–60 (HR 1.45; 95% CI: 1.18-1.76) and??= 60. Conclusion Lower levels of kidney function were associated with higher rates of death, AMI hospitalization, and major bleeding among patients taking clopidogrel after hospitalization for ACS.
机译：背景慢性肾脏疾病（CKD）与急性冠脉综合征（ACS）患者的预后差有关。 CKD对接受氯吡格雷治疗的ACS患者纵向结局的影响知之甚少。方法采用回顾性队列研究设计，我们确定了退伍军人事务部（VA）于2005年1月1日至1/10/10期间住院的ACS患者，他们因氯吡格雷出院。使用门诊血清肌酐值，使用CKD-EPI方程计算估计的肾小球滤过率[eGFR（1.73？ml / min / m 2 ）]。使用Cox比例风险模型检查了eGFR与死亡率，急性心肌梗死（AMI）的住院和重大出血之间的关联。结果在7413例ACS住院并出院服用氯吡格雷的患者中，有34.5％的eGFR 30–60和11.6％的eGFRα= 60，eGFR 30–60的患者（HR 1.45; 95％CI：1.18-1.76）和？ = 60.结论ACS住院后服用氯吡格雷的患者肾功能低下与死亡率较高，AMI住院和大出血有关。

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