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首页> 外文期刊>BMC Neuroscience >Morphological correlates of injury-induced reorganization in primate somatosensory cortex
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Morphological correlates of injury-induced reorganization in primate somatosensory cortex

机译：灵长类体感皮层损伤诱导重组的形态学相关性

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Background Topographic reorganization of central maps following peripheral nerve injury has been well characterized. Despite extensive documentation of these physiological changes, the underlying anatomical correlates have yet to be fully explored. In this study, we used Golgi impregnation and light microscopy to assess dendritic morphology following denervation of the glabrous hand surface in adult primates. Results After survival durations that permit complete physiologically-defined reorganization, we find a systematic change in the dendritic arborization pattern of both layer II/III pyramidal and layer IV spiny stellate cells in the contralateral hand region of area 3b, compared to unaffected cortical areas. In general, our analyses indicate a progressive expansion of distal regions of the dendritic arbor with no appreciable changes proximally. This pattern of distal dendritic elaboration occurs for both basilar and apical dendrites. Conclusions These observations are consistent with the notion that latent inputs gain expression in reorganized cortex after nerve injury via their influence through contacts with more distally located termination sites.
机译：背景已经很好地表征了周围神经损伤后中央地图的地形重组。尽管有大量关于这些生理变化的文献记载，但潜在的解剖学相关性尚未完全探究。在这项研究中，我们使用高尔基浸渍和光学显微镜来评估成年灵长类动物无毛手表面去神经后的树突形态。结果在存活时间允许完全的生理学上确定的重组之后，我们发现与未受影响的皮质区域相比，区域3b的对侧手区域的II / III层锥体和第四层棘状星状细胞的树突状树突模式发生了系统性变化。一般而言，我们的分析表明树突状乔木的远端区域逐渐扩张，而近端没有明显变化。远端树突的这种模式在基底和顶端树突中均会发生。结论这些观察结果与这样的观点是一致的，即潜在输入在神经损伤后通过与远端位置更远的末端接触而受到影响而在重组皮质中表达。

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