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首页> 外文期刊>BMC Neuroscience >The effects of isatin (indole-2, 3-dione) on pituitary adenylate cyclase-activating polypeptide-induced hyperthermia in rats
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The effects of isatin (indole-2, 3-dione) on pituitary adenylate cyclase-activating polypeptide-induced hyperthermia in rats

机译：靛红（吲哚-2、3-二酮）对垂体腺苷酸环化酶激活多肽诱导的大鼠体温过高的影响

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Background Previous studies have demonstrated that centrally administered natriuretic peptides and pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) have hyperthermic properties. Isatin (indole-2, 3-dione) is an endogenous indole that has previously been found to inhibit hyperthermic effects of natriuretic peptides. In this study the aim was to investigate the effects of isatin on thermoregulatory actions of PACAP-38, in rats. Results One μg intracerebroventricular (icv.) injection of PACAP-38 had hyperthermic effect in male, Wistar rats, with an onset of the effect at 2 h and a decline by the 6th h after administration. Intraperitoneal (ip.) injection of different doses of isatin (25-50 mg/kg) significantly decreased the hyperthermic effect of 1 μg PACAP-38 (icv.), whereas 12.5 mg/kg isatin (ip.) had no inhibiting effect. Isatin alone did not modify the body temperature of the animals. Conclusion The mechanisms that participate in the mediation of the PACAP-38-induced hyperthermia may be modified by isatin. The capability of isatin to antagonize the hyperthermia induced by all members of the natriuretic peptide family and by PACAP-38 makes it unlikely to be acting directly on receptors for natriuretic peptides or on those for PACAP in these hyperthermic processes.
机译：背景技术先前的研究表明，集中施用的利钠肽和垂体腺苷酸环化酶激活多肽38（PACAP-38）具有高温特性。 Isatin（吲哚-2，3-dione）是一种内源性吲哚，以前已发现它可以抑制利钠肽的高温效应。在这项研究中，目的是研究异黄酮对大鼠PACAP-38体温调节作用的影响。结果1μg的脑室内（icv。）注射PACAP-38在雄性Wistar大鼠中具有热疗作用，在2 h起效，在给药后第6 h下降。腹膜内（ip。）注射不同剂量的isatin（25-50 mg / kg）可以显着降低1μgPACAP-38（icv。）的高温效应，而12.5 mg / kg isatin（ip​​。）没有抑制作用。单独使用Isatin不会改变动物的体温。结论Isatin可能参与了参与PACAP-38引起的体温过高调节的机制。胰蛋白酶拮抗利钠肽家族的所有成员和PACAP-38诱导的体温过高的能力，使其不太可能直接作用于利钠肽或PACAP受体。

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