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首页> 外文期刊>BMC Neuroscience >Electrocortical effects of MDMA are potentiated by acoustic stimulation in rats
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Electrocortical effects of MDMA are potentiated by acoustic stimulation in rats

机译：大鼠的听觉刺激增强了MDMA的电皮层效应

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Background 3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) is known for its toxicological, psychopathological and abuse potential. Some environmental conditions, e.g. acoustic stimulation typical of the "rave scene" can influence the toxicity of this drug. Results We investigated the effects of low doses of MDMA in vivo using Wistar rats in the absence of acoustic stimulation (white noise; 95 Db) demonstrating that ecstasy is able to induce a significant activation (reduction of Electrocortical total power) of the telencephalic cortex that spontaneously reverts in the absence of sensorial stimuli, whereas it persists for several days if, in addition to MDMA, the animals are exposed to acoustic stimulation. Conclusion Our data demonstrate that low doses of MDMA are able to reduce electrocortical total power, and that this effect is potentiated by sensorial stimuli commonly present in certain environments, such as rave parties.
机译：背景技术3，4-亚甲基二氧基甲基苯丙胺（摇头丸;摇头丸）以其毒理学，心理病理学和滥用潜力而闻名。一些环境条件，例如“狂欢场面”的典型声刺激会影响该药的毒性。结果我们研究了在没有声刺激（白噪声; 95 Db）的情况下，使用Wistar大鼠在体内低剂量MDMA的影响，证明了摇头丸能够诱导显着激活（降低皮层总皮质醇）的脑皮质。在没有感觉刺激的情况下会自发恢复，而如果除了MDMA之外，动物还受到声刺激，它会持续几天。结论我们的数据表明，低剂量的MDMA能够降低皮层总电功率，并且这种作用被某些环境（如狂欢派对）中普遍存在的感觉刺激所增强。

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