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首页> 外文期刊>BMC Neuroscience >Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation
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Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation

机译：在成人海马神经发生中双皮质激素相关的树突成熟的变异性独立于前体细胞增殖的调节

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Background In the course of adult hippocampal neurogenesis most regulation takes place during the phase of doublecortin (DCX) expression, either as pro-proliferative effect on precursor cells or as survival-promoting effect on postmitotic cells. We here obtained quantitative data about the proliferative population and the dynamics of postmitotic dendrite development during the period of DCX expression. The question was, whether any indication could be obtained that the initiation of dendrite development is timely bound to the exit from the cell cycle. Alternatively, the temporal course of morphological maturation might be subject to additional regulatory events. Results We found that (1) 20% of the DCX population were precursor cells in cell cycle, whereas more than 70% were postmitotic, (2) the time span until newborn cells had reached the most mature stage associated with DCX expression varied between 3 days and several weeks, (3) positive or negative regulation of precursor cell proliferation did not alter the pattern and dynamics of dendrite development. Dendrite maturation was largely independent of close contacts to astrocytes. Conclusion These data imply that dendrite maturation of immature neurons is initiated at varying times after cell cycle exit, is variable in duration, and is controlled independently of the regulation of precursor cell proliferation. We conclude that in addition to the major regulatory events in cell proliferation and selective survival, additional micro-regulatory events influence the course of adult hippocampal neurogenesis.
机译：背景技术在成年海马神经发生的过程中，大多数调节发生在双皮质素（DCX）表达阶段，作为对前体细胞的促增殖作用或对有丝分裂后细胞的促生存作用。在这里，我们获得了有关DCX表达期间增殖种群和有丝分裂后枝晶发育动力学的定量数据。问题是，是否可以获得任何迹象表明枝晶发育的启动与细胞周期的退出是否及时相关。或者，形态成熟的时间过程可能会受到其他调节事件的影响。结果我们发现（1）DCX群体中有20％是细胞周期的前体细胞，而70％以上是有丝分裂后的（2）直到新生细胞达到与DCX表达相关的最成熟阶段的时间跨度在3几天和几周的时间，（3）前体细胞增殖的正向或负向调节都不会改变枝晶发育的模式和动力学。树突的成熟很大程度上独立于与星形胶质细胞的紧密接触。结论这些数据表明，未成熟神经元的树突成熟是在细胞周期退出后的不同时间开始的，其持续时间是可变的，并且不受前体细胞增殖调控的控制。我们得出结论，除了细胞增殖和选择性存活中的主要调控事件外，其他微调控事件也会影响成年海马神经发生的过程。

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