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首页> 外文期刊>BMC Neuroscience >Rearing in enriched environment increases parvalbumin-positive small neurons in the amygdala and decreases anxiety-like behavior of male rats
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Rearing in enriched environment increases parvalbumin-positive small neurons in the amygdala and decreases anxiety-like behavior of male rats

机译：在丰富的环境中饲养会增加杏仁核中小白蛋白阳性小神经元的数量，并减少雄性大鼠的焦虑样行为

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Background Early life experiences including physical exercise, sensory stimulation, and social interaction can modulate development of the inhibitory neuronal network and modify various behaviors. In particular, alteration of parvalbumin-expressing neurons, a gamma-aminobutyric acid (GABA)ergic neuronal subpopulation, has been suggested to be associated with psychiatric disorders. Here we investigated whether rearing in enriched environment could modify the expression of parvalbumin-positive neurons in the basolateral amygdala and anxiety-like behavior. Results Three-week-old male rats were divided into two groups: those reared in an enriched environment (EE rats) and those reared in standard cages (SE rats). After 5 weeks of rearing, the EE rats showed decreased anxiety-like behavior in an open field than the SE rats. Under another anxiogenic situation, in a beam walking test, the EE rats more quickly traversed an elevated narrow beam. Anxiety-like behavior in the open field was significantly and negatively correlated with walking time in the beam-walking test. Immunohistochemical tests revealed that the number of parvalbumin-positive neurons significantly increased in the basolateral amygdala of the EE rats than that of the SE rats, while the number of calbindin-D28k-positive neurons did not change. These parvalbumin-positive neurons had small, rounded soma and co-expressed the glutamate decarboxylase (GAD67). Furthermore, the number of parvalbumin-positive small cells in the basolateral amygdala tended to positively correlate with emergence in the center arena of the open field and negatively correlated with walking time in the beam walking test. Conclusion Rearing in the enriched environment augmented the number of parvalbumin-containing specific inhibitory neuron in the basolateral amygdala, but not that of calbindin-containing neuronal phenotype. Furthermore, the number of parvalbumin-positive small neurons in the basolateral amygdala was negatively correlated with walking time in the beam walking test and tended to be positively correlated with activity in the center arena in the open field test. The results suggest that rearing in the enriched environment augmented parvalbumin-positive specific neurons in the basolateral amygdala, which induced behavioral plasticity that was reflected by a decrease in anxiety-like behavior in anxiogenic situations.
机译：背景技术包括体育锻炼，感觉刺激和社交互动在内的早期生活经验可以调节抑制性神经元网络的发育并改变各种行为。特别是，已表明表达小白蛋白的神经元（γ-氨基丁酸（GABA）能神经元亚群）的改变与精神疾病有关。在这里，我们研究了在丰富的环境中饲养是否可以修饰基底外侧杏仁核中小白蛋白阳性神经元的表达和焦虑样行为。结果将三周大的雄性大鼠分为两组：在富集环境中饲养的动物（EE大鼠）和在标准笼中饲养的动物（SE大鼠）。饲养5周后，EE大鼠在空旷地域的焦虑样行为比SE大鼠减少。在另一种焦虑症的情况下，在电子束行走测试中，EE大鼠更快地穿过了升高的窄电子束。在电子束行走测试中，空旷地区的焦虑样行为与行走时间显着负相关。免疫组织化学测试显示，EE大鼠的基底外侧杏仁核中小白蛋白阳性神经元的数量比SE大鼠明显增加，而calbindin-D28k阳性神经元的数量没有变化。这些小白蛋白阳性神经元的躯体较小且呈圆形，并且共表达谷氨酸脱羧酶（GAD67）。此外，在束外侧行走测试中，基底外侧杏仁核中小白蛋白阳性小细胞的数量与空旷中心区域的出现呈正相关，与行走时间呈负相关。结论在丰富的环境中饲养可增加基底外侧杏仁核中含小白蛋白的特异性抑制神经元的数量，但不会增加含钙结合蛋白的神经元表型的数量。此外，在束步行试验中，基底外侧杏仁核中小白蛋白阳性小神经元的数量与步行时间呈负相关，而在开放视野试验中，与中心区域的活动呈正相关。结果表明，在丰富的环境中饲养会增加基底外侧杏仁核中小白蛋白阳性的特定神经元，从而诱发行为可塑性，这反映在焦虑发生时焦虑样行为的减少。

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