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首页> 外文期刊>BMC Pediatrics >A Multi-Center, Qualitative Assessment of Pediatrician and Maternal Perspectives on Rotavirus Vaccines and the Detection of Porcine circovirus
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A Multi-Center, Qualitative Assessment of Pediatrician and Maternal Perspectives on Rotavirus Vaccines and the Detection of Porcine circovirus

机译：儿科医生和产妇对轮状病毒疫苗和猪圆环病毒的检测的多中心，定性评估

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Background In 2010, researchers using novel laboratory techniques found that US-licensed rotavirus vaccines contain DNA or DNA fragments from Porcine circovirus (PCV), a virus common among pigs but not believed to cause illness in humans. We sought to understand pediatricians' and mothers' perspectives on this finding. Methods We conducted three iterations of focus groups for pediatricians and non-vaccine hesitant mothers in Seattle, WA, Cincinnati, OH, and Rochester, NY. Focus groups explored perceptions of rotavirus disease, rotavirus vaccination, and attitudes about the detection of PCV material in rotavirus vaccines. Results Pediatricians understood firsthand the success of rotavirus vaccines in preventing severe acute gastroenteritis among infants and young children. They measured this benefit against the theoretical risk of DNA material from PCV in rotavirus vaccines, determining overall that the PCV finding was of no clinical significance. Particularly influential was the realization that the large, randomized clinical trials that found both vaccines to be highly effective and safe were conducted with DNA material from PCV already in the vaccines. Most mothers supported the ideal of full disclosure regarding vaccination risks and benefits. However, with a scientific topic of this complexity, simplified information regarding PCV material in rotavirus vaccines seemed frightening and suspicious, and detailed information was frequently overwhelming. Mothers often remarked that if they did not understand a medical or technical topic regarding their child's health, they relied on their pediatrician's guidance. Many mothers and pediatricians were also concerned that persons who abstain from pork consumption for religious or personal reasons may have unsubstantiated fears of the PCV finding. Conclusions Pediatricians considered the detection of DNA material from PCV in rotavirus vaccines a "non-issue" and reported little hesitation in continuing to recommend the vaccines. Mothers desired transparency, but ultimately trusted their pediatrician's recommendation. Both vaccines are currently approved for their intended use, and no risk of human PCV illness has been reported. Communicating this topic to pediatricians and mothers requires sensitivity to a broad range of technical understanding and personal concerns.
机译：背景技术2010年，研究人员使用新颖的实验室技术发现，美国许可的轮状病毒疫苗含有猪圆环病毒（PCV）的DNA或DNA片段，该病毒在猪中很常见，但据信不会引起人类疾病。我们试图了解儿科医生和母亲对这一发现的看法。方法我们对华盛顿州西雅图市，俄亥俄州辛辛那提市和纽约州罗切斯特市的儿科医生和非疫苗犹豫母亲进行了三组焦点小组讨论。专题小组探讨了对轮状病毒疾病的认识，轮状病毒疫苗的接种以及对轮状病毒疫苗中PCV物质检测的态度。结果儿科医生对轮状病毒疫苗在预防婴幼儿严重急性肠胃炎方面的成功具有第一手的了解。他们针对轮状病毒疫苗中PCV的DNA物质的理论风险评估了这一益处，从而总体上确定PCV的发现没有临床意义。特别有影响力的是认识到，使用疫苗中已经含有PCV的DNA材料进行的大型随机临床试验发现这两种疫苗都是高效和安全的。大多数母亲支持关于疫苗接种风险和益处的全面披露的理想。但是，以这种复杂性为主题，有关轮状病毒疫苗中PCV物质的简化信息似乎令人恐惧和可疑，而详细信息却常常令人难以理解。母亲经常说，如果他们不了解有关孩子健康的医学或技术话题，他们将依靠儿科医生的指导。许多母亲和儿科医生还担心出于宗教或个人原因而放弃食用猪肉的人可能对PCV的发现缺乏事实依据的恐惧。结论儿科医生认为从轮状病毒疫苗中检测PCV的DNA物质是“非问题”，并报告在继续推荐疫苗方面毫不犹豫。母亲们希望透明，但最终还是相信儿科医生的建议。两种疫苗目前均已批准用于其预期用途，并且尚未报告有人类PCV疾病的风险。与儿科医生和母亲交流这个话题需要对广泛的技术理解和个人关注保持敏感。

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