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首页> 外文期刊>BMC Neuroscience >The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats
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The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats

机译：脑室内给予orexin受体2型拮抗剂对戊四氮诱发的大鼠癫痫发作和焦虑的影响

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Current antiepileptic drugs are not able to prevent recurrent seizures in all patients. Orexins are excitatory hypothalamic neuropeptides that their receptors (Orx1R and Orx2R) are found almost in all major regions of the brain. Pentylenetetrazol (PTZ)-induced kindling is a known experimental model for epileptic seizures. The purpose of this study was to evaluate the effect of Orx2 receptor antagonist (TCS OX2 29) on seizures and anxiety of PTZ-kindled rats. Our results revealed that similar to valproate, administration of 7?μg/rat of TCS OX2 29 increased the latency period and decreased the duration time of 3rd and 4th stages of epileptiform seizures. Besides, it significantly decreased mean of seizure scores. However, TCS OX2 29 did not modulate anxiety induced by repeated PTZ administration. This study showed that blockade of Orx2 receptor reduced seizure-related behaviors without any significant effect on PTZ-induced anxiety.
机译：当前的抗癫痫药不能防止所有患者反复发作。食欲素是兴奋性下丘脑神经肽，其受体（Orx1R和Orx2R）几乎存在于大脑的所有主要区域。戊四氮（PTZ）诱导的点燃是癫痫发作的已知实验模型。这项研究的目的是评估Orx2受体拮抗剂（TCS OX2 29）对PTZ点燃的大鼠的癫痫发作和焦虑的影响。我们的研究结果表明，与丙戊酸盐相似，给予7？μg/大鼠的TCS OX2 29可延长潜伏期，并缩短癫痫发作第3和第4阶段的持续时间。此外，它显着降低了癫痫发作分数的平均值。然而，TCS OX2 29不能调节由重复PTZ给药引起的焦虑。这项研究表明，阻断Orx2受体可以减少癫痫发作相关的行为，而对PTZ诱发的焦虑没有任何显着影响。

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