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首页> 外文期刊>BMC Neuroscience >Gastrodin protects dopaminergic neurons via insulin-like pathway in a Parkinson’s disease model
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Gastrodin protects dopaminergic neurons via insulin-like pathway in a Parkinson’s disease model

机译：天麻素通过帕金森氏病模型中的胰岛素样途径保护多巴胺能神经元

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Recently, the use of traditional Chinese medicine (TCM) has become more generally accepted, including by the Food and Drug Administration. To expand the use of TCM worldwide, it is important to study the molecular mechanisms by which TCM and its active ingredients produce effects. Gastrodin is an active ingredient from Gastrodia elata Blume. It is reported that gastrodin has neuroprotective function in Parkinson’s disease. But its mechanisms of neuroprotection remain not clear in PD. Here, we build two C. elegans PD model using 6-OHDA and transgenic animal to observe the changes of PD worms treated with or without gastrodin to confirm the function of gastrodin, then utilize mutant worms to investigate DAF-2/DAF-16 signaling pathway, and finally verify the mechanism of gastrodin in PD. Gastrodin attenuates the accumulation of α-synuclein and the injury of dopaminergic neurons, improves chemotaxis behavior in Parkinson’s?disease models, then recovers chemotaxis behavior by insulin-like pathway. DAF-2/DAF-16 is required for neuroprotective effect of dopamine neuron in PD. Our study demonstrated that gastrodin rescued dopaminergic neurons and reduced accumulation of α-synuclein protein, and the activity of gastrodin against Parkinson’s disease depended on the insulin-like DAF-2/DAF-16 signaling pathway. Our findings revealed that this insulin-like pathway mediates neuroprotection of gastrodin in a Parkinson’s disease model.
机译：最近，包括食品和药物管理局在内的中药（TCM）的使用已变得更加普遍。为了在世界范围内扩大中药的应用，研究中药及其有效成分产生作用的分子机制非常重要。天麻素是天麻的有效成分。据报道天麻素对帕金森氏病具有神经保护作用。但其神经保护机制尚不清楚。在这里，我们使用6-OHDA和转基因动物建立了两个秀丽隐杆线虫PD模型，观察用或不用天麻素处理的PD蠕虫的变化，以确认天麻素的功能，然后利用突变蠕虫研究DAF-2 / DAF-16信号传导途径，最后验证天麻素在PD中的作用机理。天麻素减弱α-突触核蛋白的积累和多巴胺能神经元的损伤，改善帕金森病模型中的趋化行为，然后通过胰岛素样途径恢复趋化行为。 DAF-2 / DAF-16是多巴胺对PD的神经保护作用所必需的。我们的研究表明，天麻素能挽救多巴胺能神经元并减少α-突触核蛋白的积累，并且天麻素对帕金森氏病的活性取决于胰岛素样DAF-2 / DAF-16信号通路。我们的发现表明，这种类似胰岛素的途径在帕金森氏病模型中介导天麻素的神经保护作用。

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