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首页> 外文期刊>BMC Neuroscience >Brain arousal regulation and depressive symptomatology in adults with attention-deficit/hyperactivity disorder (ADHD)
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Brain arousal regulation and depressive symptomatology in adults with attention-deficit/hyperactivity disorder (ADHD)

机译：注意缺陷多动障碍（ADHD）成年人的脑唤醒调节和抑郁症状

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The aim of the present study was to evaluate the stability of brain arousal in adult attention-deficit/hyperactivity disorder (ADHD) outpatients with and without depressive symptomatology, and its association with depressive symptom severity and absolute electroencephalogram (EEG) power in different frequency bands. We included 31 outpatient adults (45.16% females), who were diagnosed according to DSM-IV and received no medication. Their arousal stability score (index of the steepness of arousal decline during a 15-min EEG under resting conditions), the absolute EEG power and self-reports, including depressive and ADHD-related symptoms, were analyzed. Participants were split into an unstable and stable arousal group based on the median (=?6) of the arousal stability score. ADHD patients in the stable group reported more severe depressive symptoms (p?=?0.018) and showed reduced absolute EEG power in the delta (0.002?≤?p?≤?0.025) and theta (0.011?≤?p?≤?0.034) bands compared to those in the unstable group. There was no correlation between the arousal stability score and self-report-scales concerning ADHD-related symptoms (0.214?≤?p?≤?0.989), but a positive association with self-reported depressive severity (p?=?0.018) and negative association with powers in the EEG delta and theta bands (0.001?≤?p?≤?0.033). In view of high comorbidity of depression and ADHD in adult patients, these findings support the assumption that brain arousal regulation could be considered as a helpful marker for the clinical differentiation between ADHD and depression.
机译：本研究的目的是评估在有和没有抑郁症状的成人注意力缺陷/多动障碍（ADHD）门诊患者中脑唤醒的稳定性，以及其与抑郁症状的严重程度和不同频段的绝对脑电图（EEG）的关系。 。我们纳入了31位门诊成人（女性占45.16％），他们根据DSM-IV被诊断出并没有接受药物治疗。分析了他们的觉醒稳定性评分（静息状态下15分钟脑电图中觉醒下降的陡度指数），绝对脑电功率和自我报告，包括抑郁和与ADHD相关的症状。根据唤醒稳定性评分的中位数（=？6），将参与者分为不稳定和稳定的唤醒组。稳定组的多动症患者报告了更严重的抑郁症状（p = 0.018），并且在绝对值（0.002≤p≤0.025）和θ（0.011≤p≤0.034）方面显示绝对脑电功率降低。 ）频段与不稳定组的频段相比。与多动症相关症状的觉醒稳定性评分和自我报告量表之间没有相关性（0.214≤p≤0.989），与自我报告的抑郁严重程度呈正相关（p ＝ 0.018）和与EEG三角带和θ带中的幂呈负相关（0.001≤≤p≤0.033）。鉴于成人抑郁症和ADHD的高合并症，这些发现支持这样的假设，即大脑觉醒调节可被认为是ADHD和抑郁症临床区别的有用标志。

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