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Anaemia in HIV-infected children: severity, types and effect on response to HAART

机译：艾滋病毒感染儿童的贫血：严重程度，类型及其对HAART反应的影响

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Background HIV and anaemia are major health challenges in Africa. Anaemia in HIV-infected individuals is associated with more rapid disease progression and a poorer prognosis if not addressed appropriately. This study aimed at determining the severity and types of anaemia among HIV infected children and its effect on short term response to antiretroviral therapy (ART). Methods At baseline, clinical and haematological parameters of 257 HIV-infected ART-na?ve children aged 3 months to 18 years were assessed to determine the prevalence, severity and types of anaemia. ART eligible patients were started on therapy according to WHO criteria, enrolled (n=88) into an observational cohort and followed up for 6 months. Results Anaemia was present in 148/257 (57.6%) of children, including (93/148) 62.2% with mild anaemia, 47/148 (32.0%) moderate anaemia, and 7/148 (4.8%) with severe anaemia. The mean haemoglobin (hb) was lower among children with more advanced HIV disease (p Conclusion Anaemia is highly prevalent among HIV-infected children in a rural Ugandan clinic and is associated with poorer virological suppression. However, the anaemia did not impact clinical and immunological response to ART among these children.
机译：背景技术HIV和贫血是非洲的主要健康挑战。如果未适当解决，HIV感染者的贫血与疾病进展更快和预后较差有关。这项研究旨在确定感染HIV的儿童中贫血的严重程度和类型及其对抗逆转录病毒疗法（ART）短期反应的影响。方法基线时，评估了257名3个月至18岁的初次感染HIV的纯稚儿童的临床和血液学参数，以确定贫血的患病率，严重程度和类型。符合ART要求的患者根据WHO标准开始治疗，纳入（n = 88）观察性队列，并随访6个月。结果148/257（57.6％）儿童出现贫血，包括（93/148）62.2％的轻度贫血，47/148（32.0％）的中度贫血和7/148（4.8％）的严重贫血。晚期艾滋病毒感染儿童的平均血红蛋白（hb）较低（p结论乌干达农村诊所的艾滋病毒感染儿童中贫血非常普遍，并且与较弱的病毒学抑制有关，但是，贫血并未影响临床和免疫学这些孩子对ART的反应。

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