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首页> 外文期刊>BMC Neuroscience >Serotonin 5-HT 2A and 5-HT 6 receptors in the prefrontal cortex of Alzheimer and normal aging patients
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Serotonin 5-HT 2A and 5-HT 6 receptors in the prefrontal cortex of Alzheimer and normal aging patients

机译：阿尔茨海默氏症和正常衰老患者前额叶皮质的5-羟色胺5-HT 2A和5-HT 6受体

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Background It has been hypothesized that alterations of the serotonergic system contribute to neuropsychiatric symptoms in Alzheimer disease (AD). Cellular expressions of the two serotonergic receptors 5-HT2A and 5-HT6 have therefore been determined by immunohistochemistry in the prefrontal cortex of patients with AD (n=6) and normal age-matched controls (n = 7). Results In normal aging patients, 5-HT2A label was mainly observed in large pyramidal cells, but to a lesser extent also in small pyramidal cells and in stellate cells of cortical layers II-VI. In AD, a similar distribution was observed, but density of positive cells was significantly reduced by 33%. In aging control patients, the 5-HT6 receptor was expressed by pyramidal cells and occasional stellate cells, not only of layers II-V, but also of layer I, where a distinct label was observed in neurons and surrounding fibers. 5-HT6 receptor expression in AD patients had the same pattern, but was significantly decreased by 40%. Conclusion Our results indicate that a decline in neurons expressing 5-HT2A, but also 5-HT6 receptors may play a role in the etiopathology of neuropsychiatric symptoms in AD.
机译：背景已经假设血清素能系统的改变有助于阿尔茨海默氏病（AD）的神经精神症状。因此，通过免疫组织化学法确定了AD（n = 6）和AD患者前额叶皮层中两种5-羟色胺能受体5-HT 2A 和5-HT 6 的细胞表达。正常年龄匹配的对照组（n = 7）。结果在正常衰老患者中，主要在大型锥体细胞中观察到5-HT 2A 标记，但在较小的锥体细胞和皮质层II-VI的星状细胞中观察到的程度较小。在AD中，观察到相似的分布，但是阳性细胞的密度显着降低了33％。在衰老对照患者中，锥体细胞和偶尔的星状细胞表达5-HT 6 受体，不仅是II-V层，还有I层，在神经元中观察到明显的标记和周围的纤维。 AD患者5-HT 6 受体的表达模式相同，但明显降低了40％。结论我们的结果表明，表达5-HT 2A 但5-HT 6 受体的神经元减少可能与AD神经精神症状的病因有关。

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