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首页> 外文期刊>BMC Pediatrics >Nutritional status, intestinal parasite infection and allergy among school children in Northwest Ethiopia
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Nutritional status, intestinal parasite infection and allergy among school children in Northwest Ethiopia

机译：埃塞俄比亚西北部学龄儿童的营养状况，肠道寄生虫感染和过敏

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Background Parasitic infections have been shown to have deleterious effects on host nutritional status. In addition, although helmintic infection can modulate the host inflammatory response directed against the parasite, a causal association between helminths and allergy remains uncertain. The present study was therefore designed to evaluate the relationship between nutritional status, parasite infection and prevalence of allergy among school children. Methods A cross sectional study was performed involving school children in two elementary schools in Gondar, Ethiopia. Nutritional status of these children was determined using anthropometric parameters (weight-for-age, height-for-age and BMI-for-age). Epi-Info software was used to calculate z-scores. Stool samples were examined using standard parasitological procedures. The serum IgE levels were quantified by total IgE ELISA kit following the manufacturer’s instruction. Result A total of 405 children (with mean age of 12.09.1?±?2.54 years) completed a self-administered allergy questionnaire and provided stool samples for analysis. Overall prevalence of underweight, stunting and thinness/wasting was 15.1%, 25.2%, 8.9%, respectively. Of the total, 22.7% were found to be positive for intestinal parasites. The most prevalent intestinal parasite detected was Ascaris lumbricoides (31/405, 7.6%). There was no statistically significant association between prevalence of malnutrition and the prevalence of parasitic infections. Median total serum IgE level was 344 IU/ml (IQR 117–2076, n?=?80) and 610 IU/ml (143–1833, n?=?20), respectively, in children without and with intestinal parasite infection (Z?=??0.198, P?>?0.8). The prevalence of self reported allergy among the subset was 8%. IgE concentration was not associated either with the presence of parasitic infection or history of allergy. Conclusion The prevalence of malnutrition, intestinal parasitism and allergy was not negligible in this population. In addition, there was no significant association between the prevalence of allergy and their nutritional status, and parasite infection. Further research prospective observational and intervention studies are required to address the question of causality between nutritional factors, parasites, and allergy.
机译：背景技术已显示出寄生虫感染对宿主的营养状况具有有害影响。另外，尽管蠕虫感染可以调节针对寄生虫的宿主炎症反应，但蠕虫和过敏之间的因果关系仍然不确定。因此，本研究旨在评估营养状况，寄生虫感染和小学生过敏患病率之间的关系。方法在埃塞俄比亚贡德尔的两所小学对学童进行了横断面研究。使用人体测量学参数（年龄体重，年龄身高和年龄BMI）确定这些孩子的营养状况。 Epi-Info软件用于计算z得分。使用标准的寄生虫学程序检查粪便样品。按照制造商的说明，通过总IgE ELISA试剂盒对血清IgE水平进行定量。结果共有405名儿童（平均年龄为12.09.1±2.54岁）填写了一份自我过敏问卷，并提供了粪便样本进行分析。体重过轻，发育不良和瘦弱/浪费的总体患病率分别为15.1％，25.2％和8.9％。在总数中，发现22.7％的肠道寄生虫呈阳性。检测到的最普遍的肠道寄生虫是A虫（Ascaris lumbricoides）（31 / 405，7.6％）。营养不良患病率与寄生虫感染患病率之间无统计学意义的关联。在没有和有肠道寄生虫感染的儿童中，血清总IgE水平分别为344 IU / ml（IQR 117-2076，n？=？80）和610 IU / ml（143-1833，n？=？20）（ Z≥0.198，P≥0.8）。该子集中自我报告的过敏症患病率为8％。 IgE浓度与寄生虫感染或过敏史无关。结论该人群营养不良，肠道寄生虫病和过敏的发生率不可忽略。此外，过敏症的流行及其营养状况与寄生虫感染之间没有显着关联。需要进行进一步的前瞻性观察和干预研究，以解决营养因素，寄生虫和过敏之间的因果关系问题。

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