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首页> 外文期刊>BMC Pediatrics >Maternal and neonatal outcomes in pregnant women with autoimmune diseases in Pavia, Italy
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Maternal and neonatal outcomes in pregnant women with autoimmune diseases in Pavia, Italy

机译：意大利帕维亚患有自身免疫性疾病的孕妇的孕产妇和新生儿结局

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The increased number of childbearing women with autoimmune diseases leads to a growing interest in studying relationship among maternal disease, therapy, pregnancy and off-spring. The aim of this study was to determine the impact of autoimmune disease on pregnancy and on neonatal outcome, taking into account the maternal treatment and the transplacental autoantibodies passage. We studied 70 infants born to 70 pregnant women with autoimmune disease attended in Fondazione IRCCS Policlinico San Matteo, Pavia, Italy from June 2005 to June 2012. Maternal and neonatal characteristics were collected and relevant clinical, laboratory, therapeutics, sonographic and electrocardiographic investigations were recorded and analyzed. We observed a high rate of spontaneous abortions in medical history, 29?%, and 18.6?% of preterm births and 22.9?% of low birth weight (< 2500?g). Transplacental autoantibodies passage wasn’t related to maternal or obstetrical complication, but anti-Ro/SSA positive pregnancies correlated with abnormal fetal heart rate (P?=?0.01). Pregnant women on therapy showed an higher incidence of maternal (p?=?0.002), obstetric (p?=?0.007) complications and an increased rate of intrauterine growth restriction (p?=?0.01) than the untreated ones. Autoimmune diseases in pregnancy require to be carefully monitored to ensure the best possible management of mothers, fetuses and newborns due to the high rate of morbidity specially in case of maternal polytherapy and/or anti-Ro/SSA positivity.
机译：患有自身免疫性疾病的育龄妇女人数的增加，导致人们对研究孕产妇疾病，治疗方法，妊娠和后代之间的关系越来越感兴趣。这项研究的目的是确定孕产妇的治疗和经胎盘自身抗体的传递，从而确定自身免疫性疾病对妊娠和新生儿结局的影响。我们研究了2005年6月至2012年6月在意大利帕维亚Fondazione IRCCS Policlinico San Matteo住院的70例自身免疫性疾病孕妇所生的70例婴儿。收集了母婴特征，并记录了相关的临床，实验室，治疗方法，超声检查和心电图检查并进行分析。在病史中，我们发现自然流产发生率很高，分别为早产的29％和18.6％，低出生体重（<2500µg）的22.9％。经胎盘自身抗体的通过与母亲或产科并发症无关，但抗Ro / SSA阳性妊娠与胎儿心率异常相关（P = 0.01）。与未治疗的孕妇相比，接受治疗的孕妇产妇（p？=？0.002），产科（p？=？0.007）并发症的发生率和宫内生长受限率（p？=？0.01）升高。妊娠期间自身免疫性疾病需要仔细监控，以确保母亲，胎儿和新生儿的最佳控制，因为其发病率很高，尤其是在母体综合疗法和/或抗Ro / SSA阳性的情况下。

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